| Revue: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290763 |
| ISSN: | 1413-8670 |
| Autores: | Lopes, Edmundo P.A1 Valente, Lucila M2 Silva, A. Eduardo B1 Kirsztajn, Gianna Mastroianni2 Cruz, Cibele N1 Ferraz, Maria Lucia G1 |
| Instituciones: | 1Universidade Federal de Sao Paulo, Divisao de Gastroenterologia, Sao Paulo. Brasil 2Universidade Federal de Sao Paulo, Divisao de Nefrologia, Sao Paulo. Brasil |
| Año: | 2003 |
| Periodo: | Oct |
| Volumen: | 7 |
| Número: | 5 |
| Paginación: | 353-357 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | We describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an improvement in renal disease was seen after 6 months of therapy. However, after 9 months, Case 2 presented ALT elevation, and proteinuria was detected. Two years after the end of therapy, both patients were negative in repeated HCV-RNA and cryoglobulin tests. Case 1 was asymptomatic, with normal liver and renal tests, and Case 2 had normal blood pressure, with mild edema of the ankles. Based on the evolution of these two cases, the association of IFN-alpha and ribavirin may be a therapeutic option for patients with MPGN related to HCV |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Nefrología, Terapéutica y rehabilitación, Glomerulonefritis, Hepatitis C, Interferón, Ribavirina |
| Keyword: | Medicine, Gastroenterology, Nephrology, Therapeutics and rehabilitation, Glomerulonephritis, Hepatitis C, Interferon, Ribavirin |
| Texte intégral: | Texto completo (Ver HTML) |
