| Revue: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290865 |
| ISSN: | 1413-8670 |
| Autores: | Silva, Claudia da1 Goncales, Neiva Sellan Lopes Pereira, Josiane Silveira Felix Escanhoela, Cecilia Amelia Fazzio Pavan, Maria Helena Postal Goncales-Junior, Fernando Lopes1 |
| Instituciones: | 1Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, Sao Paulo. Brasil |
| Año: | 2004 |
| Periodo: | Oct |
| Volumen: | 8 |
| Número: | 6 |
| Paginación: | 431-439 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | Occult hepatitis B virus (HBV) infections have been identified in patients with chronic hepatitis C virus (HCV) infection, although the clinical relevance of occult HBV infection remains controversial. We searched for serum HBV DNA in 106 HBsAg negative/anti-HBc positive patients with chronic HCV infection and in 150 blood donors HBsAg negative/anti-HBc positive/anti-HCV negative (control group) by nested-PCR. HCV genotyping was done in 98 patients and percutaneous needle liver biopsies were performed in 59 patients. Fifty-two patients were treated for HCV infection with interferon alone (n=4) or combined with ribavirin (n=48) during one year. At the end and 24 weeks after stopping therapy, they were tested for HCV-RNA to evaluate the sustained virological response (SVR). Among the 106 HCV-positive patients, 15 (14%) were HBV-DNA positive and among the 150 HCV-negative blood donors, 6 (4%) were HBV-DNA positive. Liver biopsy gave a diagnosis of liver cirrhosis in 2/10 (20%) of the HBV-DNA positive patients and in 6/49 (12%) of the HBV-DNA negative patients. The degree of liver fibrosis and portal inflammation was similar in HCV-infected patients HBV-DNA, irrespective of HBV-DNA status. SVR was obtained in 37.5% of the HBV-DNA positive patients and in 20.5% of the HBV-DNA negative patients; this difference was not significant. In conclusion, these data suggested that occult HBV infection, which occurs at a relatively high frequency among Brazilian HCV-infected patients, was not associated with more severe grades of inflammation, .. |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Hepatitis C, Terapéutica y rehabilitación, Infecciones crónicas, Interferón |
| Keyword: | Medicine, Gastroenterology, Hepatitis C, Therapeutics and rehabilitation, Chronic infections, Interferon |
| Texte intégral: | Texto completo (Ver HTML) |
