| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290896 |
| ISSN: | 1413-8670 |
| Autores: | Gales, Ana C1 Jones, Ronald N2 Andrade, Soraya S Pereira, Andrea S Sader, Helio S |
| Instituciones: | 1Universidade Federal de Sao Paulo, Divisao de Doencas Infecciosas, Sao Paulo. Brasil 2The JMI Laboratories, North Liberty, Iowa. Estados Unidos de América |
| Año: | 2005 |
| Periodo: | Oct |
| Volumen: | 9 |
| Número: | 5 |
| Paginación: | 348-356 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | The in vitro activity of tigecycline (former GAR-936), a new semisynthetic tetracycline, was evaluated in comparison with tetracycline and other antimicrobial agents. A total of 1,326 contemporary clinical isolates collected from the Latin American region were collected in 2000-2002 period and tested with microdilution broth according to the CLSI guidelines. The bacterial pathogens evaluated included Staphylococcus aureus (505), Streptococcus pneumoniae (269), coagulase-negative staphylococci (CoNS; 227), Haemophilus influenzae (129), Enterococcus spp. (80), Moraxella catarrhalis (54), beta-haemolytic streptococci (28), viridans group streptococci (26), and Neisseria meningitidis (8) Tigecycline demonstrated excellent activity against all Gram-positive cocci, with 90% of penicillin-resistant S. pneumoniae strains being inhibited at 0.12 µg/mL, while the same isolates had an MIC90 of > 16 µg/mL for tetracycline. All Enterococcus spp. were inhibited at 0.25 µg/mL of tigecycline. Tigecycline (MIC50, 0.25 µg/mL) was eight-fold more potent than minocycline (MIC50, 2 µg/mL) against oxacillin-resistant S. aureus (ORSA); all ORSA were inhibited at < 2 µg/mL of tigecycline. Tigecycline demonstrated excellent activity (MIC50, 0.5 µg/mL) against CoNS with reduced susceptibility to teicoplanin (MIC, 16 µg/mL). Tigecycline also showed high potency against respiratory pathogens such as M. catarrhalis (MIC50, 0.12 µg/mL) and H. influenzae (MIC50, 0.5 µg/mL). No tigecycline resistant isolates were detected when |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Microbiología, Susceptibilidad antimicrobiana, Tigeciclina, Staphylococcus aureus, Streptococcus pneumoniae |
| Keyword: | Medicine, Microbiology, Pharmacology, Antimicrobial susceptibility, Tigecycline, Staphylococcus aureus, Streptococcus pneumoniae |
| Texto completo: | Texto completo (Ver HTML) |
