| Revue: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290760 |
| ISSN: | 1413-8670 |
| Autores: | Caterino-de-Araujo, Adele1 Santos-Fortuna, Elizabeth de los1 Carbone, Paulo Henrique Lage2 Cibella, Sandra Elisa Lopes1 Moreira, Abdiel Aparecido2 |
| Instituciones: | 1Instituto Adolfo Lutz, Sao Paulo. Brasil 2Universidade de Sao Paulo, Sao Paulo. Brasil |
| Año: | 2003 |
| Periodo: | Dic |
| Volumen: | 7 |
| Número: | 6 |
| Paginación: | 395-401 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | ABSTRACT BACKGROUND: With the spread of AIDS, many HIV-infected women have been diagnosed with Kaposi's sarcoma (KS), especially in Africa. Since the discovery of a novel herpesvirus as the causative agent of KS (human herpesvirus 8 — HHV-8) several seroepidemiological studies have been conducted to identify groups at risk for KS. The risk for women in Brazil has not been studied. MATERIALS AND METHODS: We searched for HHV-8 antibodies in sera obtained from a bank made up of samples from 3 groups of individuals: Group I: 163 HIV-1-infected women attended at an ambulatory clinic in 1994; Group II: 108 children born to HIV-1-infected mothers from 1990 to 1992, their antibodies reflected maternal infection, and Group III: 630 HIV-1-seronegative, healthy women. In-house immunofluorescence and Western-Blot assays based on the BCBL-1 cell line were used to detect anti-latent and anti-lytic HHV-8 antibodies. RESULTS: Group I had an overall frequency of antibodies of 8.6%, with a 1.2% frequency of anti-latent antibodies and an 8.0% frequency of anti-lytic antibodies. Similar results were detected in Group II, i.e., no cases with anti-latent antibodies and a 7.4% frequency of anti-lytic antibodies. In contrast, prevalences of 1.1% anti-latent antibodies and 0.3% anti-lytic antibodies were observed in Group III. CONCLUSIONS: The epidemiologic pattern of HHV-8 in women from São Paulo varies according to behavioral factors, with emphasis on the sexual and blood routes of virus transmission/acquisition. Although HHV-8 anti-lytic antibodies were found in HIV-1-infected women, no case of KS was detected. Protective factors against KS are probably related to gender and/or to antiretroviral therapies introduced in Brazil since 1994 |
| Disciplinas: | Biología, Medicina |
| Palabras clave: | Inmunología, Virus, Salud pública, Herpesvirus humano - 8, Infección HHV-8, Mujeres, VIH-1, Seroprevalencia, Sarcoma de Kaposi |
| Keyword: | Biology, Medicine, Immunology, Virus, Public health, Human herpesvirus-8, HHV-8 infection, Women, HIV-1, Seroprevalence, Kaposi sarcoma |
| Texte intégral: | Texto completo (Ver HTML) |
