| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290746 |
| ISSN: | 1413-8670 |
| Autores: | Munerato, Patricia1 Azevedo, Maria Lucia Sucupira, Maria Cecilia Araripe Pardini, Regina Pinto, Gedson Humberto Novaes Catroxo, Marcia Souza, Inara Espinelli Diaz, Ricardo Sobhie |
| Instituciones: | 1Universidade Federal de Sao Paulo, Laboratorio de Retrovirologia, Sao Paulo. Brasil |
| Año: | 2003 |
| Periodo: | Ago |
| Volumen: | 7 |
| Número: | 4 |
| Paginación: | 236-240 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including CCR2B and CCR3, function as minor co-receptors. A 32-nucleotide deletion (delta32) within the beta-chemokine receptor 5 gene (CCR5) has been described in subjects who remain uninfected despite extensive exposition to HIV-1. The heterozygous genotype delays disease progression. This allele is common among Caucasians, but has not been found in people of African or Asian ancestry. A more common transition involving a valine to isoleucine switch in transmembrane domain I of CCR2B (64I), with unknown functional consequences, was found to delay disease progression but not to reduce infection risk. As the Brazilian population consists of a mixture of several ethnic groups, we decided to examine the genotype frequency of these polymorphisms in this country. There were 11.5% CCR5 heterozygotes among the HIV-1 infected population and 12.5% among uninfected individuals, similar to data from North America and Western Europe. The prevalence of CCR2-64I homozygotes and heterozygotes was 0.06 and 15.2%, respectively, also similar to what is known for North America and Western Europe |
| Disciplinas: | Química |
| Palabras clave: | Bioquímica, Inmunología, Genética, Heterocigotos CCR2B, Infección, VIH-1, Polimorfismo, Quimiocinas |
| Keyword: | Chemistry, Biochemistry, CCR5 Heterozygotes, Infections, HIV-1, Polymorphism, Chemokines, Immunology, Genetics |
| Texto completo: | Texto completo (Ver HTML) |
