| Revista: | Revista médica del Hospital General de México |
| Base de datos: | |
| Número de sistema: | 000602844 |
| ISSN: | 0185-1063 |
| Autores: | Padilla Pérez, Javier1 López Canales, Oscar A1 Castillo Hernández, María C1 Padilla Keymole, Javier2 López Canales, Jorge Skiold1 Zambrano Padilla, Ramón3 |
| Instituciones: | 1Instituto Politécnico Nacional, Escuela Superior de Medicina, Ciudad de México. México 2Concordia University, Computer Science, Montreal, Quebec. Canadá 3Centennial College, Digital Animation, Toronto, Ontario. Canadá |
| Año: | 2023 |
| Periodo: | Jul-Sep |
| Volumen: | 86 |
| Número: | 3 |
| Paginación: | 93-98 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Resumen en inglés | Background: Phenylephrine (PHE) produces higher aortothoracic contractile tension with endothelium (TON) compared to potassium chloride (KCl). Both are exponential triphasic responses (Φ1, Φ2, Φ3) but their kinetics have not been compared with the time constant (τ in s). Goal. To study the triphasic TOn kinetics (τ: Φ1, Φ2(fundamental) and Φ3) of 1μM PHE vs 40mM KCl. Material and methods: We compared numerical values of τ1, τ2, τ3 of the TOn of prepubertal male Wistar rats (without established reproductive capacity) with adult male ones. Results: Φ2 showed higher gain (g), shorter delay time (s), and faster kinetics of TOn at PHE than at KCl. Conclusions: In the time course of TOn only the fundamental exponential phase was faster with PHE than with KCl. |
| Disciplinas: | Medicina, Medicina, Medicina |
| Palabras clave: | Medicina experimental, Sistema cardiovascular, Farmacología |
| Keyword: | Experimental medicine, Cardiovascular system, Pharmacology |
| Texto completo: | Texto completo (Ver PDF) Texto completo (Ver HTML) |
