| Revue: | Revista médica de Chile |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000317485 |
| ISSN: | 0034-9887 |
| Autores: | Bravo, María Verónica1 Bunout, Daniel Leiva, Laura Maza, María Pía de la Barrera, Gladys De la Maza, Javier Hirsch, Sandra |
| Instituciones: | 1Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos, Santiago de Chile. Chile |
| Año: | 2008 |
| Periodo: | Ago |
| Volumen: | 136 |
| Número: | 8 |
| Paginación: | 981-988 |
| País: | Chile |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | ntibiotic-associated diarrhea is one of the most common adverse effects of antimicrobials. Any antimicrobial can potentially produce diarrhea but beta-lactamics have a higher risk. Among these, amoxicillin is widely indicated in ambulatory practice. One ofthe alternatives suggested to prevent antibiotic-associated diarrhea, is the use of the probiotic Saccharomyces boulardii. Aim: To evalúate whether the concomitant use of Saccharomyces boulardii and amoxicillin can prevent antibiotic associated diarrhea in ambulatory adults with acute infections diseases, without provoking other adverse effects. Material and Methods: Eighty six adults (aged 15 to 81 years) with acute infectious diseases, excluding those arising in the gastrointestinal tract, that received a prescription of oral amoxicillin for 5 to 10 days, were included. In a controlled randomized, double blind trial, 41 patients were assigned to receive lyophilized Saccharomyces boulardii (500 mg/day) duríng 12 days, and 45 patients were assigned to placebo for the same period. Results: Ten percent of patients (9/86) reported acute diarrhea, 9,8% (4/41) in the experimental group and 11.196 (5/45) in the control group (p = 100). No adverse effects were associated to the use of the probiotic. Conclusions: Saccharomyces boulardii (500 mg/day) did not prevent diarrhea related to amoxicillin |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Microbiología, Diarrea, Amoxicilina, Flora intestinal, Regeneración, Probióticos, Saccharomyces boulardii |
| Keyword: | Medicine, Gastroenterology, Microbiology, Diarrhea, Amoxicillin, Intestinal flora, Regeneration, Probiotics, Saccharomyces boulardii |
| Texte intégral: | Texto completo (Ver HTML) |
