| Revue: | Revista médica de Chile |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000455035 |
| ISSN: | 0034-9887 |
| Autores: | Ramírez, Felipe1 Urzúa, Alvaro1 Roblero, Juan Pablo1 Cattaneo, Máximo1 Hurtado, Carmen1 Poniachik, Jaime1 |
| Instituciones: | 1Universidad de Chile, Hospital Clínico, Santiago de Chile. Chile |
| Año: | 2022 |
| Volumen: | 150 |
| Número: | 7 |
| Paginación: | 889-895 |
| País: | Chile |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Background: Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic disease, which can progress to cirrhosis. It mainly affects middle-aged women. Its most frequent form of presentation is asymptomatic with biochemical cholestasis and the presence of antimitochondrial antibodies (AMA). Aim: To describe the epidemiological characteristics, clinical presentation and treatment for patients with PBC at a clinical hospital. Material and Methods: Descriptive, observational, retrospective study, carried out between January 2015 and December 2020. Results: 179 patients (158 women) were cared in the study period. At the time of diagnosis, the median age was 54 years (range 24-76), 55% of them were asymptomatic, 45% had fatigue and 28% had pruritus. Positive AMA were present in 65% of patients, antinuclear antibodies (ANA) in 51%, and anti-smooth muscle antibodies (ASMA) in 9%. Immunoglobulin M (IgM) was elevated in 30% of the patients and 50% of patients were biopsied. Splenomegaly and esophageal varices were present in 24 and 22% of patients, respectively. PBC was associated with Sjogren's syndrome in 15%, hypothyroidism in 14%, osteoporosis in 13%, and scleroderma in 8%. Conclusions: The epidemiological characteristics of our patients agree with those published abroad. Laboratory cholestasis associated with the presence of AMA, currently allows diagnosis without the need for histological study. Ursodeoxycholic acid (UDCA) is the first-line treatment for patients with PBC. The use of biochemical response criteria is essential to identify patients who require other UDCA alternatives for isolated or combined treatment |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Inmunología, Enfermedades autoinmunes, Cirrosis hepática, Colangitis biliar primaria, Acido ursodeoxicólico |
| Keyword: | Gastroenterology, Immunology, Autoimmune diseases, Liver cirrhosis, Primary biliary cholangitis, Ursodeoxycholic acid |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
