| Revista: | Revista latinoamericana de hipertensión |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000437781 |
| ISSN: | 1856-4550 |
| Autores: | Golmohammadzadeh, Golpar1 Mohammadpour, Abbas1 Ahangar, Nematollah1 Shokrzadeh, Mohammad1 |
| Instituciones: | 1Mazandaran University of Medical Sciences, Faculty of Pharmacy, Sari. Irán |
| Año: | 2019 |
| Volumen: | 14 |
| Número: | 5 |
| Paginación: | 525-536 |
| País: | Venezuela |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Breast cancer is the first leading cause of cancer-related death in women. Xenobiotic-Metabolizing Enzymes (XMEs) contribute to the detoxification of numerous cancer therapy-induced products. In the metabolism of xenobiotics, cytochrome P450s or monooxygenases and Glutathione –s transferase (GSTs) perform an important function by catalyzing the hydroxylation reaction andconjugationofglutathione( GSH) to a wide variety of xenobiotics. Pesticides, which are excessively used in northern Iran, are one of the mostimportant risk factors for breast cancer incidence. They detoxify by phase I and II enzymes. The aim of this study was to evaluate the association of CYP1A1(rs4646421 ),CYP1B1(rs1056836),CYP2C8(rs1058930),CYP19A1( rs749292) and GSTP1(rs 1695) polymorphisms and serum levels of pesticides (Diazinon and Malathion) with the risk of breast cancer in Mazandaran province. This crosssectional case-control study included 72 patients and 51 healthy individuals who were recruited.It wasperformed betweenOctober 2017 to May 2018 in Oncology department at Imam Hospital inSari City.Breast cancer patients with knownclinicopathological characters and healthy women, as control, were genotyped for genes polymorphisms by PCR-RFLP and GC-MS method used for quantification of poisons.Chisquare test, Fisher exact test,and logistic regression model were applied for statistical analysis. The results of the experiments showed that there weresignificant relationships between two groups and the age of the patients wassignificantly higher than the control group(p = 0.044). Regarding the relationship between the genotypes of each gene and breast cancer risk, using a logistic regression model in two normalized and age-adjusted models, it was determined that in CYP2C8 genotype, those havingtheCGallele, increased the risk of breast cancer in adjusted model (CI=95%1.11,75.84). In the CYP19A1gene of individuals with GA genotype |
| Disciplinas: | Medicina |
| Palabras clave: | Oncología, Toxicología, Genética, Cáncer, Mama, Etiología, Plaguicidas, Diazinon, Malation, Polimorfismo genético |
| Keyword: | Oncology, Toxicology, Genetics, Cancer, Breast, Etiology, Pesticides, Diazinon, Malathion, Genetic polymorphism |
| Texto completo: | http://biblat.unam.mx/hevila/Revistalatinoamericanadehipertension/2019/vol14/no5/3.pdf |
