| Revue: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454096 |
| ISSN: | 0034-8376 |
| Autores: | Jaime Pérez, José C1 Cancela Murrieta, Carlos O1 Salazar Cavazos, Lorena1 Aguilar Calderón, Patrizia E1 Salazar Riojas, Rosario1 Méndez Ramírez, Nereida1 Cantú Rodríguez, Olga G1 Gutiérrez Aguirre, César H1 Gómez Almaguer, David1 |
| Instituciones: | 1Universidad Autónoma de Nuevo León, Hospital Universitario Dr. José Eleuterio González, Monterrey, Nuevo León. México |
| Año: | 2020 |
| Periodo: | Mar-Abr |
| Volumen: | 72 |
| Número: | 2 |
| Paginación: | 69-79 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Background: The impact of HLA-DPB1 compatibility and its role as a transplantation antigen in haploidentical-related hematopoietic stem cell transplant (haplo-R-HSCT) have not been established, and a negative effect on survival has been suggested. Objective: The objective of the determine was to study the frequency and clinical effects of incompatibility at the HLA-DPB1 locus in the haplo-R-HSCT setting. Methods: Clinical records and electronic files of 91 patients with a hematological disease who underwent haplo-HSCT from January 2009 to October 2017 in a university medical center were scrutinized. Overall survival (OS) was estimated by the Kaplan–Meier method; the cumulative incidence of transplant-related mortality (TRM) and relapse rates was determined. Acute graft-versus-host disease was assessed by binary logistic regression. Cox regression model with a 95% confidence interval was used to examine the association between the different variables and their effect on OS. Results: Of the 91 donor-recipient pairs, 24 (26.37%) shared complete DPB1 identity, 60 (65.93%) had a mismatch at one allele, and 7 (7.70%) were mismatched at two alleles. Twenty-four different HLA-DPB1 alleles were found; the most frequent were DPB1*04:01 (34.1%) and DPB1*04:02 (27.5%). Two-year OS, the cumulative incidence of TRM and relapse was 51.3 ± 6.8%, 28 ± 6% and 60 ± 7.8% for all haplo-related transplants, respectively, with no statistical difference between HLA-DPB1 matched and partially matched patients. In Cox regression analysis, no risk factors associated with OS, TRM, or relapses were identified. Conclusion: HLA-DPB1 mismatching in the haplo-R-HSCT setting did not influence transplant outcomes and was clinically tolerable. A high degree of homozygosity was found |
| Disciplinas: | Medicina |
| Palabras clave: | Hematología, Inmunología, Trasplante de células hematopoyéticas, Antígeno leucocitario humano, Compatibilidad |
| Keyword: | Hematology, Immunology, Hematopoietic cells transplantation, Human leukocyte antigen, Compatibility |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
