| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454111 |
| ISSN: | 0034-8376 |
| Autores: | Esparza López, José2 Martínez Aguilar, Juan F1 Ibarra Sánchez, María de J2 |
| Instituciones: | 1Universidad Nacional Autónoma de México, Coordinación de la Investigación Científica, Ciudad de México. México 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Unidad de Bioquímica, Ciudad de México. México |
| Año: | 2019 |
| Periodo: | Nov-Dic |
| Volumen: | 71 |
| Número: | 6 |
| Paginación: | 369-380 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Cancer is the second-leading cause of death in the world, accounting for one out of six deaths. Consequently, there is an urgent need for new and more effective therapeutic options as well as drug screening methods. Immortal, “stable” cancer cell lines have been employed since the past century to assess drug response but face several disadvantages. They often accumulate new genetic aberrations due to long-term culture and lack the indisputable heterogeneity of solid tumors, therefore, compromising the recapitulation of molecular features from parental tumors. Primary cancer cells have emerged as an attractive alternative to commercial cell lines since they can preserve such properties more closely. Here, we provide an overview of the basic concepts underlying generation and characterization of primary cell cultures from tumor samples. We emphasize the advantages and disadvantages of using these types of cancer cell cultures, and we make a comparison with other types of cultures used for personalized therapy. Finally, we consider the use of primary cancer cell cultures in personalized therapy as a means to improve drug response prediction and therapeutic outcomes |
| Disciplinas: | Medicina |
| Palabras clave: | Oncología, Terapéutica y rehabilitación, Cáncer, Células cancerosas primarias, Medicina personalizada |
| Keyword: | Oncology, Therapeutics and rehabilitation, Cancer, Primary cancer cells, Personalized medicine |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
