| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454110 |
| ISSN: | 0034-8376 |
| Autores: | Aguilar Navarro, Sara G1 Mimenza Alvarado, Alberto J1 Jiménez Castillo, Gilberto A1 Bracho Vela, Leonardo A1 Yeverino Castro, Sara G1 Avila Funes, José A2 |
| Instituciones: | 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Programa de Medicina Geriátrica y Neurología, Ciudad de México. México 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Geriatría, Ciudad de México. México |
| Año: | 2019 |
| Periodo: | Nov-Dic |
| Volumen: | 71 |
| Número: | 6 |
| Paginación: | 381-386 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Background It has been proposed that Vitamin D helps reduce the accumulation of cerebral β-amyloid-42 by innate immune stimulation and phagocytosis activation. An association between low Vitamin D levels and Alzheimer’s dementia (AD) has been established. We determined the association between Vitamin D, mild cognitive impairment (MCI), and AD in older Mexican adults (> 65 years) Methods Cross-sectional study conducted at the memory clinic in a tertiary-level hospital in Mexico City. We evaluated subjects with MCI, AD, and normal cognition (NC) with available serum Vitamin D [25(OH)D] levels (past 6 months). Three categories were assigned according to 25(OH)D levels: sufficiency (> 30 ng/mL), insufficiency (21-29 ng/mL), and deficiency (≤ 20 ng/mL). Descriptive statistics, means and standard deviations were used. Logistic regression analyses adjusted by age, sex, and educational level were performed Results We evaluated 208 patients. Mean age was 79 ± 1 year, 65% (n = 136) were female; and mean educational level was 6.7 ± 2.3 years. Thirty-one subjects (14%) had NC; 42% (n = 88) had MCI; and 43% (n = 89) had AD. Prevalence of Vitamin D deficiency was 54%, more frequent in the AD group (64%) followed by the MCI (59%) and NC (13%) (p < 0.001) groups. In the multivariate logistic regression analysis, Vitamin D deficiency was associated with MCI (HR 25.02 [confidence interval 95% 4.48-139]; p < 0.001) and AD (HR 41.7 [5.76-301]; p < 0.001) after adjusting for confounders Conclusions Serum Vitamin D deficiency was associated with MCI and dementia; low levels produced a greater effect over executive functions |
| Disciplinas: | Medicina |
| Palabras clave: | Neurología, Geriatría, Farmacología, Vitamina D, Deterioro cognitivo leve, Demencia, Enfermedad de Alzheimer, Ancianos |
| Keyword: | Neurology, Geriatrics, Pharmacology, Vitamin D, Mild cognitive impairment, Dementia, Alzheimer disease, Aged |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
