| Revue: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000313464 |
| ISSN: | 0100-4042 |
| Autores: | Pereira, Darcio Gomes1 |
| Instituciones: | 1Galeno Research Unit, Campinas, Sao Paulo. Brasil |
| Año: | 2007 |
| Periodo: | Feb |
| Volumen: | 30 |
| Número: | 1 |
| Paginación: | 171-177 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Descriptivo, divulgación |
| Resumen en inglés | It is widely recognized that pharmacokinetic optimization needs to be addressed early in drug discovery to reduce the high failure rate in bringing drugs to market. Poor absorption, too short duration of action due to high elimination rate, or the presence of active metabolites are examples of properties that can potentially lead to unsuccessful clinical programmes. Here I describe a brief overview of advantages and molecular strategies for improving metabolic and pharmacokinetic properties applied to the discovery of fluconazol, beta-blockers, ritonavir and ezetimibe and to the development of the prodrugs enalapril and bambuterol |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Metabolismo, Diseño de fármacos, Drugs in pregnancy |
| Keyword: | Chemistry, Medicinal chemistry, Metabolism, Drug design, Drugs |
| Texte intégral: | Texto completo (Ver HTML) |
