| Revista: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000313233 |
| ISSN: | 0100-4042 |
| Autores: | Rodríguez, Vania1 Moura, Sidnei Pinto, Ernani Pereira, Claudio M.P Braga, Rodolpho Campos2 |
| Instituciones: | 1Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas, Sao Paulo. Brasil 2Universidade de Sao Paulo, Instituto de Quimica, Sao Paulo. Brasil |
| Año: | 2006 |
| Periodo: | Nov |
| Volumen: | 29 |
| Número: | 6 |
| Paginación: | 1365-1371 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Anatoxin-a and its analogues are azabicyclic alkaloids that represent one of the most powerful nicotinic agonists known for the nicotinic acetylcholine receptor (nAChR). Because of this potent mechanism of action, anatoxin-a and its derivatives represent a target for the discovery of novel drugs. Their syntheses are useful for environmental monitoring and also for pharmacokinetic/pharmacodynamic and toxicological studies. Some strategies for the synthesis of anatoxin-a and analogous compounds are described herein, covering the period from 1996 to the present date. In this review, emphasis is given to the chemical and toxicological aspects of some variants of anatoxin-a, including homoanatoxin-a and anatoxin-a(s) |
| Disciplinas: | Química |
| Palabras clave: | Bioquímica, Química farmacéutica, Algas, Anatoxina-a, Alcaloides, Toxicidad |
| Keyword: | Chemistry, Biochemistry, Medicinal chemistry, Algae, Anatoxin-a, Alkaloids, Toxicity |
| Texto completo: | Texto completo (Ver HTML) |
