| Revue: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000196596 |
| ISSN: | 0100-4042 |
| Autores: | Dias, Ricardo L. Araujo1 Correa, Arlene G |
| Instituciones: | 1Universidade Federal de Sao Carlos, Departamento de Quimica, Sao Carlos, Sao Paulo. Brasil |
| Año: | 2001 |
| Periodo: | Mar-Abr |
| Volumen: | 24 |
| Número: | 2 |
| Paginación: | 236-242 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Teórico, divulgación |
| Resumen en inglés | Combinatorial Chemistry has become a very efficient methodology in drug research. Recent progress in combinatorial synthesis performed both in solid and solution phase have led to a change in the paradigm for the identification and optimization of lead compounds. This article gives an overview of the principal characteristics of combinatorial libraries and some examples of the application of this methodology in the identification of test compounds and lead compound optimization, either from synthetic or natural sources |
| Disciplinas: | Química |
| Palabras clave: | Fitoquímica, Química farmacéutica, Química orgánica, Química combinatoria, Desarrollo de fármacos, Fase sólida, Productos naturales, Optimación |
| Keyword: | Chemistry, Medicinal chemistry, Organic chemistry, Phytochemistry, Combinatorial chemistry, Drug development, Solid phase, Natural products, Optimization |
| Texte intégral: | Texto completo (Ver HTML) |
