Effect of crosslinking agents on chitosan microspheres in controlled release of diclofenac sodium



Título del documento: Effect of crosslinking agents on chitosan microspheres in controlled release of diclofenac sodium
Revue: Polimeros (Sao Carlos)
Base de datos: PERIÓDICA
Número de sistema: 000314223
ISSN: 1678-5169
Autores: 1


2
Instituciones: 1Universidade Federal de Sao Carlos, Departamento de Quimica, Sao Carlos, Sao Paulo. Brasil
2Universidade Federal de Sao Carlos, Departamento de Bioquimica, Sao Carlos, Sao Paulo. Brasil
Año:
Periodo: Ene-Mar
Volumen: 15
Número: 1
Paginación: 6-12
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés In this work chitosan microspheres were prepared by the simple coacervation method and crosslinked using epichlorhydrin or glutaraldehyde for the controlled release of diclofenac sodium. The effects of the crosslinking agents on chitosan microspheres over a 12-hour period were assessed with regard to swelling, hydrolysis, porosity, crosslinking, impregnation of diclofenac sodium (DS), and consequently to the release of DS in buffer solutions, simulating the gastrointestinal tract. The degree of swelling varied with the pH for glutaraldehyde chitosan microspheres (GCM) and epichlorhydrin chitosan microspheres (ECM). Partial acid and basic hydrolysis affected the swelling behavior of the GCM matrix. Release kinetics of diclofenac sodium from these matrices were investigated at pH 1.2, 6.8 and 9.0, simulating the gastrointestinal tract conditions. The results indicated that the release mechanism deviated slightly from Fickian transport
Disciplinas: Química
Palabras clave: Bioquímica,
Química farmacéutica,
Reticulación,
Quitosano,
Microesferas,
Diclofenaco sódico,
Liberación controlada
Keyword: Chemistry,
Biochemistry,
Medicinal chemistry,
Crosslinking,
Chitosan,
Diclofenac-sodium,
Microspheres,
Controlled release
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