| Revista: | Pesquisa veterinaria brasileira |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000301499 |
| ISSN: | 0100-736X |
| Autores: | Spilki, Fernando R1 Esteves, Paulo A Franco, Ana Claudia Lima, M Holz, Carine L Batista, Helena Beatriz R Driemeier, David2 Flores, Eduardo Furtado3 Weiblen, Rudi Roehe, Paulo M |
| Instituciones: | 1Centro de Pesquisas Veterinarias Desiderio Finamor, Eldorado do Sul, Rio Grande do Sul. Brasil 2Universidade Luterana do Brasil, Faculdade de Veterinaria, Canoas, Rio Grande do Sul. Brasil 3Universidade Federal de Santa Maria, Departamento de Medicina Veterinaria Preventiva, Santa Maria, Rio Grande do Sul. Brasil |
| Año: | 2002 |
| Periodo: | Abr-Jun |
| Volumen: | 22 |
| Número: | 2 |
| Paginación: | 58-63 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | In order to determine the capacity of bovine herpesvirus type 1 and 5 (BHV-1 and BHV-5) to invade, multiply and spread along the central nervous system (CNS) (neuroinvasiveness), as well as their potential to induce neurological illness (neurovirulence), 30 to 35 days old rabbits were inoculated with the BHV-5 strain EVI 88 / 95 and Los Angeles and Cooper BHV-1 strains, by the intrathecal (IT) and intranasal (IN) routes. The BHV-5 strain induced severe neurological clinical signs in 100% (12/12) of the rabbits inoculated by both routes. Histopathological examination revealed multifocal non-suppurative meningoencephalitis, characterized by multifocal gliosis and perivascular cuffing. Virus was recovered from many parts of the brain. Both BHV-1 strains, when inoculated via IT route, were not neurovirulent. The strain Los Angeles, after IN inoculation, induced signs of severe respiratory disease (7/7), as well as signs of neurological impairment, indistinguishable from those induced by BHV-5, in 57% (4/7) of the infected rabbits. However, the rabbits with nervous signs revealed at histopathology vasculitis and thrombosis in lungs and brain, the latter with foci of neuronal necrosis, but no lesions indicative of encephalitis, suggesting that neural damage was probably consequent to tissue anoxia. The BHV-1 strain Cooper, after IN inoculation, induced only mild signs of respiratory disease. These findings indicate that the BHV-5 strain was both neuroinvasive and neurovirulent, since it was capable of invading, spreading and multiplying |
| Disciplinas: | Medicina veterinaria y zootecnia, Biología |
| Palabras clave: | Medicina veterinaria, Virus, Rinotraqueitis infecciosa bovina, Herpesvirus bovino, Encefalitis bovina, Conejos, Animales de laboratorio |
| Keyword: | Veterinary medicine and animal husbandry, Biology, Veterinary medicine, Virus, Infectious bovine rhinotracheitis, Bovine herpesvirus, Bovine encephalitis, Rabbits, Laboratory animals |
| Texto completo: | Texto completo (Ver HTML) |
