| Revista: | Pesquisa veterinaria brasileira |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000301429 |
| ISSN: | 0100-736X |
| Autores: | Bezerra-Junior, Pedro Soares1 Ilha, Marcia Regina Silva Langohr, Ingeborg Maria Barros, Claudio S.L2 |
| Instituciones: | 1Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul. Brasil 2Universidade Federal de Santa Maria, Departamento de Patologia, Santa Maria, Rio Grande do Sul. Brasil |
| Año: | 2000 |
| Periodo: | Jul-Sep |
| Volumen: | 20 |
| Número: | 3 |
| Paginación: | 102-108 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | Seven horses were experimentally treated with sodium monensin. Two of them were fed 3-4 kg/horse/day with a commercial ration (containing 180 ppm±20) known to be implicated in natural outbreaks of monensin poisoning in horses. A third horse was fed a single dose of 5 mg/kg and another one received four daily doses of 1 mg/kg of sodium monensin (from a premix source). These four horses died or were euthanitised in extremis 3-8 days after the beginning of administration of the drug. A fifth horse was fed a single dose of 5 mg/kg of monensin, became mildly ill but recovered. Two experimental horses did not develop signs of the toxicosis. One of them was fed 40 daily doses of 0.5 mg/kg of monensin. The other was fed 3 kg/day of the same brand of ration used in farms where outbreaks of monensin poisoning in horses have been reported (but from another batch later determined to have monensin levels of only <5 ppm). The onset of clinical signs varied from 2 to 5 days after administration of the drug, and clinical courses lasted from 24 to 76 hours. Clinical signs included tachycardia and cardiac arythmia, groaning, incoordination, sudoresis, sternal or lateral recumbency, paddling and death. Marked increases in the plasmatic activity of creatine phosphokinase were observed in five poisoned horses, and a mild increase in the aspartate aminotransferase plasmatic activity was detected in one of the animals. Main necropsy findings were in the skeletal muscles and consisted of focal to focally extensive white or yellow areas of discoloration |
| Disciplinas: | Medicina veterinaria y zootecnia |
| Palabras clave: | Equinos, Medicina veterinaria, Histopatología, Antibióticos ionóforos, Monensina, Intoxicación experimental, Miopatías |
| Keyword: | Veterinary medicine and animal husbandry, Equines, Veterinary medicine, Histopathology, Ionophores antibiotics, Monensin, Myopathies, Experimental intoxication |
| Texto completo: | Texto completo (Ver HTML) |
