| Revue: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000446398 |
| ISSN: | 0074-0276 |
| Autores: | Tort, Luis Fernando Lopez1 Ribeiro, Ieda Pereira1 Menezes, Lidiane Souza Raphael1 dos Santos, Alexandre Araújo Cunha1 Santos, Marta Pereira1 Damasceno, Luana2 Silva, Paola Cristina Resende1 Siqueira, Marilda Agudo Mendonça Teixeira de1 Brasil, Patricia2 Bonaldo, Myrna Cristina1 |
| Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Fundacao Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro. Brasil |
| Año: | 2021 |
| Volumen: | 116 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.33-derived lineage named N.9 was described recently in Brazil and it’s considered a potential variant of interest (VOI) due to the presence of E484K substitution at the receptor-binding domain (RBD) of the Spike (S) protein. To describe the first detection of variant N.9 in Rio de Janeiro State. SARS-CoV-2 N.9 was confirmed by quantitative reverse transcription polymerase chain reaction (qRT-PCR), whole-genome sequencing and phylogenetic analysis. Here, we report two SARS-CoV-2 N.9 lineage strains in Rio de Janeiro. One of them had only the E484K substitution of the six N.9 lineage-defining mutations. Other three strains pre-defined as N.9 have the same genomic profile. These four strains are grouped within the B.1.1.33 lineage and basal to the N.9 lineage in our phylogenetic analysis, and we call them “N.9-like/B.1.1.33 + E484K”. The phylogenetic analysis shows four independent introductions of N.9 in the state of Rio de Janeiro in October and December 2020, January and March 2021. SARS-CoV-2 N.9 dissemination in the Rio de Janeiro could have been limited by the emergence and dominance of other variants, mainly by the lineage P.2 VOI Zeta that emerged in the same period and co-circulated with N.9, as observed in the neighboring State of São Paulo |
| Disciplinas: | Medicina |
| Palabras clave: | Virus, Genética, COVID-19, Análisis filogenético, Variantes genéticas, Brasil |
| Keyword: | Virus, Genetics, COVID-19, Phylogenetic analysis, Genetic variants, Brazil |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
