Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco
Título del documento: Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco
Revista: Memorias do Instituto Oswaldo Cruz
Base de datos: PERIÓDICA
Número de sistema: 000349678
ISSN: 0074-0276
Autores: 1
3
4
2
1
5
2
Instituciones: 1Laboratorio Central de Saude Publica de Pernambuco, Recife, Pernambuco. Brasil
2Universidade Federal de Pernambuco, Programa de Pos-graduacao em Medicina Tropical, Recife, Pernambuco. Brasil
3Fundacao Instituto Oswaldo Cruz, Centro de Pesquisa Aggeu Magalhaes, Recife, Pernambuco. Brasil
4Centro de Testagem e Aconselhamento Herbert de Souza, Cabo de Santo Agostinho, Pernambuco. Brasil
5Universidade Federal de Sao Paulo, Laboratorio de Retrovirologia, Sao Paulo. Brasil
Año:
Periodo: Jun
Volumen: 107
Número: 4
Paginación: 450-457
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental
Resumen en inglés Determining the prevalence and type of antiretroviral (ARV) resistance among ARV-naïve individuals is important to assess the potential responses of these individuals to first-line regimens. The prevalence of primary resistance and the occurrence of recent infections among individuals with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) were identified among recently diagnosed patients at five sexually transmitted disease/AIDS testing and counselling centres in the metropolitan region of Recife (RMR), Pernambuco, Brazil, between 2007-2009. One-hundred and eight samples were analysed using the Calypte® BED assay. Males predominated (56%), as did patients aged 31-50 years. Twenty-three percent presented evidence of a recent HIV infection. The median CD4+ T lymphocyte count was 408 cells/mm3 and the median viral load was 3.683 copies/mL. The prevalence of primary resistance was 4.6% (confidence interval 95% = 1-8.2%) based on criteria that excluded common polymorphisms in accordance with the surveillance drug resistance mutation criteria. The prevalence of resistance to non-nucleoside reverse transcriptase, nucleoside/nucleotide reverse transcriptase and protease inhibitors were 3.8%, 1.5% and 0.8%, respectively. Fifty-seven percent of strains were from clade B, 37.7% were clade F and 3.1% were clade C; there were no statistically significant differences with respect to resistance between clades. Recent infection tended to be more common in men (p = 0.06) and in municipalities in the south of the RMR (Jaboatão dos Guararapes and Cabo de Santo Agostinho) (p = 0.046). The high prevalence of recent infection and the high prevalence of non-B strains in this poor Brazilian region merit further attention
Disciplinas: Biología,
Química
Palabras clave: Genética,
Virus,
Química farmacéutica,
Resistencia primaria,
Resistencia a fármacos,
Antirretrovirales,
VIH,
Infecciones,
Brasil
Keyword: Biology,
Chemistry,
Genetics,
Virus,
Medicinal chemistry,
Drug resistance,
Primary resistance,
Antiretrovirals,
HIV,
Infections,
Brazil
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