| Revue: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000446430 |
| ISSN: | 0074-0276 |
| Autores: | Souza, Hugo Amorim dos Santos de1 Escafa, Victor Fernandes1 Blanco, Carolina Moreira1 Baptista, Bárbara de Oliveira1 Barros, Jenifer Peixoto de1 Riccio, Evelyn Ketty Pratt1 Rodrigues, Aline Beatriz Mello1 Melo, Gisely Cardoso de2 Lacerda, Marcus Vinícius Guimarães de3 Souza, Rodrigo Medeiros de4 Lima-Junior, Josué da Costa1 Guimarães, Ana Carolina Ramos1 Mota, Fabio Faria da1 Silva, João Hermínio Martins da5 Daniel Ribeiro, Cláudio Tadeu1 Pratt Riccio, Lilian Rose1 Totino, Paulo Renato Rivas1 |
| Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Universidade do Estado do Amazonas, Manaus, Amazonas. Brasil 3Fundacao de Medicina Tropical do Amazonas, Instituto de Pesquisa Clinica Carlos Borborema, Manaus, Amazonas. Brasil 4Universidade Federal do Acre, Centro de Pesquisa em Doencas Infecciosas, Rio Branco, Acre. Brasil 5Fundacao Oswaldo Cruz, Eusebio, Ceara. Brasil |
| Año: | 2021 |
| Volumen: | 116 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Nota breve o noticia |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | In the present study, we investigated the genetic diversity of Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain in two municipalities of the main malaria hotspot in Brazil, i.e., the Juruá Valley, and observed complete sequence identity among all P. vivax field isolates and the Sal-1 reference strain. Analysis of PvMCA1 catalytic domain in different P. vivax genomic sequences publicly available also revealed a high degree of conservation worldwide, with very few amino acid substitutions that were not related to putative histidine and cysteine catalytic residues, whose involvement with the active site of protease was herein predicted by molecular modeling. The genetic conservation presented by PvMCA1 may contribute to its eligibility as a druggable target candidate in vivax malaria |
| Disciplinas: | Biología, Medicina |
| Palabras clave: | Protozoarios, Genética, Metacaspasas, Secuencia génica, Conservación genética, Plasmodium vivax |
| Keyword: | Protozoa, Genetics, Metacaspases, Gene sequence, Genetic conservation, Plasmodium vivax |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
