Perspectives for a new drug candidate for Chagas disease therapy



Título del documento: Perspectives for a new drug candidate for Chagas disease therapy
Revue: Memorias do Instituto Oswaldo Cruz
Base de datos: PERIÓDICA
Número de sistema: 000452425
ISSN: 0074-0276
Autores: 1
Instituciones: 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil
Año:
Volumen: 117
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, prospectivo
Resumen en inglés Chagas disease (CD), a neglected tropical illness caused by the protozoan Trypanosoma cruzi, affects more than 6 million people mostly in poor areas of Latin America. CD has two phases: an acute, short phase mainly oligosymptomatic followed to the chronic phase, a long-lasting stage that may trigger cardiac and/or digestive disorders and death. Only two old drugs are available and both present low efficacy in the chronic stage, display side effects and are inactive against parasite strains naturally resistant to these nitroderivatives. These shortcomings justify the search for novel therapeutic options considering the target product profile for CD that will be presently reviewed besides briefly revisiting the data on phosphodiesterase inhibitors upon T. cruzi
Disciplinas: Medicina
Palabras clave: Parasitología,
Farmacología,
Enfermedad de Chagas,
Desarrollo de fármacos,
Inhibidores enzimáticos,
Fosfodiesterasa,
Trypanosoma cruzi
Keyword: Parasitology,
Pharmacology,
Chagas disease,
Drug development,
Enzyme inhibitors,
Phosphodiesterase,
Trypanosoma cruzi
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