Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target



Título del documento: Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target
Revue: Memorias do Instituto Oswaldo Cruz
Base de datos: PERIÓDICA
Número de sistema: 000452419
ISSN: 0074-0276
Autores: 1
1
1
1
1
Instituciones: 1Universidade Estadual de Maringa, Laboratorio de Inovacao Tecnologica no Desenvolvimento de Farmacos e Cosmeticos, Maringa, Parana. Brasil
Año:
Volumen: 117
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Over the past years, natural products have been explored in order to find biological active substances to treat various diseases. Regarding their potential action against parasites such as trypanosomatids, specially Trypanosoma cruzi and Leishmania spp., much advance has been achieved. Extracts and purified molecules of several species from genera Piper, Tanacetum, Porophyllum, and Copaifera have been widely investigated by our research group and exhibited interesting antitrypanosomal and antileishmanial activities. These natural compounds affected different structures in parasites, and we believe that the mitochondrion is a strategic target to induce parasite death. Considering that these trypanosomatids have a unique mitochondrion, this cellular target has been extensively studied aiming to find more selective drugs, since the current treatment of these neglected tropical diseases has some challenges such as high toxicity and prolonged treatment time. Here, we summarise some results obtained with natural products from our research group and we further highlighted some strategies that must be considered to finally develop an effective chemotherapeutic agent against these parasites
Disciplinas: Medicina
Palabras clave: Parasitología,
Farmacología,
Enfermedad de Chagas,
Leishmaniasis,
Productos naturales,
Terapia alternativa,
Mitocondrias
Keyword: Parasitology,
Pharmacology,
Chagas disease,
Leishmaniasis,
Natural products,
Mitochondria,
Alternative therapy
Texte intégral: Texto completo (Ver HTML) Texto completo (Ver PDF)