Revue: | Memorias do Instituto Oswaldo Cruz |
Base de datos: | PERIÓDICA |
Número de sistema: | 000405497 |
ISSN: | 0074-0276 |
Autores: | Almeida-Paes, Rodrigo1 Brito-Santos, Fabio1 Figueiredo-Carvalho, Maria Helena Galdino1 Machado, Ana Caroline Sa1 Oliveira, Manoel Marques Evangelista1 Pereira, Sandro Antonio1 Gutierrez-Galhardo, Maria Clara1 Zancope-Oliveira, Rosely Maria1 |
Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro. Brasil |
Año: | 2017 |
Periodo: | May |
Volumen: | 112 |
Número: | 5 |
Paginación: | 376-381 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Sporothrix brasiliensis is the most virulent sporotrichosis agent. This species usually responds to antifungal drugs, but therapeutic failure can occur in some patients. Antifungal susceptibility tests have been performed on this species, but no clinical breakpoints (CBPs) are available. In this situation, minimal inhibitory concentration (MIC) distributions and epidemiological cutoff values (ECVs) support the detection of identification of resistant strains. OBJECTIVES To study the MIC distributions of five antifungal drugs against S. brasiliensis and to propose tentative ECVs. METHODS MICs of amphotericin B (AMB), itraconazole (ITR), ketoconazole (KET), posaconazole (POS), and terbinafine (TRB) against 335 S. brasiliensis strains were determined by the Clinical and Laboratory Standards Institute broth microdilution method. FINDINGS The proposed ECV, in µg/mL, for AMB, ITR, KET, POS, and TRB were 4.0, 2.0, 1.0, 2.0, and 0.25, respectively. Percentages of wild-type strains in our population for the above antifungal drugs were 98.48, 95.22, 95.33, 100, and 97.67%, respectively. MAIN CONCLUSIONS These ECVs will be useful to detect strains with resistance, to define CBPs, and to elaborate specific therapeutic guidelines for S. brasiliensis. Rational use of antifungals is strongly recommended to avoid the emergence of resistant strains and ensure the therapeutic effectiveness of sporotrichosis |
Disciplinas: | Medicina |
Palabras clave: | Farmacología, Hongos, Esporotricosis, Antifúngicos, Concentración inhibitoria mínima, Anfotericina B, Itraconazol, Ketoconazol, Posaconazol, Terbinafina, Sporothrix brasiliensis |
Keyword: | Medicine, Pharmacology, Fungi, Sporotrichosis, Antifungal agents, Minimum inhibitory concentration, Amphotericin B, Itraconazole, Ketoconazole, Posaconazole, Terbinafine, Sporothrix brasiliensis |
Texte intégral: | Texto completo (Ver HTML) |