Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni



Título del documento: Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni
Revue: Memorias do Instituto Oswaldo Cruz
Base de datos: PERIÓDICA
Número de sistema: 000371029
ISSN: 0074-0276
Autores: 1
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Instituciones: 1Fundacao Instituto Oswaldo Cruz, Centro de Pesquisa Aggeu Magalhaes, Recife, Pernambuco. Brasil
2Universidade Federal de Pernambuco, Centro de Ciencias da Saude, Recife, Pernambuco. Brasil
3Fundacao Instituto Oswaldo Cruz, Centro de Pesquisa Goncalo Moniz, Salvador, Bahia. Brasil
Año:
Periodo: Abr
Volumen: 109
Número: 2
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en portugués Undernourished mice infected (UI) submitted to low and long-lasting infections by Schistosoma mansoni are unable to develop the hepatic periportal fibrosis that is equivalent to Symmers’ fibrosis in humans. In this report, the effects of the host’s nutritional status on parasite (worm load, egg viability and maturation) and host (growth curves, biology, collagen synthesis and characteristics of the immunological response) were studied and these are considered as interdependent factors influencing the amount and distribution of fibrous tissue in hepatic periovular granulomas and portal spaces. The nutritional status of the host influenced the low body weight and low parasite burden detected in UI mice as well as the number, viability and maturation of released eggs. The reduced oviposition and increased number of degenerated or dead eggs were associated with low protein synthesis detected in deficient hosts, which likely induced the observed decrease in transformation growth factor (TGF)-β1 and liver collagen. Despite the reduced number of mature eggs in UI mice, the activation of TGF-β1 and hepatic stellate cells occurred regardless of the unviability of most miracidia, due to stimulation by fibrogenic proteins and eggshell glycoproteins. However, changes in the repair mechanisms influenced by the nutritional status in deficient animals may account for the decreased liver collagen detected in the present study
Disciplinas: Medicina,
Biología
Palabras clave: Microbiología,
Parasitología,
Infección experimental,
Esquistosomiasis,
Desnutrición,
Fibrosis hepática,
Citocinas,
Schistosoma mansoni
Keyword: Medicine,
Biology,
Microbiology,
Parasitology,
Experimental infection,
Schistosomiasis,
Malnutrition,
Liver fibrosis,
Cytokines,
Schistosoma mansoni
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