| Revue: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459444 |
| ISSN: | 0074-0276 |
| Autores: | Espíndola, Otávio1 Resende, Paola C2 Guaraldo, Lusiele1 Calvet, Guilherme Amaral1 Fuller, Trevon L3 Penetra, Stephanie Lema Suarez1 Santos, Heloisa Ferreira Pinto1 Pina Costa, Anielle1 da Silva, Michele Fernanda Borges1 Moraes, Isabella Campos Vargas1 Medeiros, Fernando1 Whitworth, Jimmy4 Smith, Christopher4 Nielsen Saines, Karin5 Siqueira, Marilda M2 Brasil, Patrícia1 |
| Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro. Brasil 2Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 3University of California at Los Angeles, Institute of the Environment and Sustainability, Los Angeles, California. Estados Unidos de América 4Liverpool School of Tropical Medicine, Department of Clinical Research, Londres. Reino Unido 5University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, California. Estados Unidos de América |
| Año: | 2023 |
| Volumen: | 118 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, descriptivo |
| Resumen en inglés | There is interest in lingering non-specific symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, referred to as Long coronavirus disease 2019 (Long COVID-19). It remains unknown whether the risk of Long COVID-19 is associated with pre-existing comorbidities or initial COVID-19 severity, including infections due to new Omicron lineages which predominated in 2023. OBJECTIVES The aim of this case report was to characterize the clinical features of acute XBB.1.5 infection followed by Long COVID-19. METHODS We followed a 73-year old female resident of Rio de Janeiro with laboratory-confirmed SARS-CoV-2 during acute infection and subsequent months. The SARS-CoV-2 lineage was determined by genome sequencing. FINDINGS The participant denied comorbidities and had completed a two-dose vaccination schedule followed by two booster doses eight months prior to SARS-CoV-2 infection. Primary infection by viral lineage XBB.1.5. was clinically mild, but the participant subsequently reported persistent fatigue. MAIN CONCLUSIONS This case demonstrates that Long COVID-19 may develop even after mild disease due to SARS-CoV-2 in fully vaccinated and boosted individuals without comorbidities. Continued monitoring of new SARS-CoV-2 lineages and associated clinical outcomes is warranted. Measures to prevent infection should continue to be implemented including development of new vaccines and antivirals effective against novel variants |
| Disciplinas: | Medicina |
| Palabras clave: | Neumología, Virus, Inmunología, SARS-CoV-2, Síndrome post-COVID-19 agudo, Evasión inmune, COVID prolongado |
| Keyword: | Pneumology, Virus, Immunology, SARS-CoV-2, Acute post-COVID-19 syndrome, Immune evasion, Long COVID |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
