| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000446423 |
| ISSN: | 0074-0276 |
| Autores: | Tavares, Victor de Souza1 de Castro, Monara Viera1 Souza, Rayane da Silva Oliveira1 Gonçalves, Iana Kátia Araújo1 Lima, Jonilson Berlink1 Borges, Valéria de Matos2 Araújo Santos, Théo1 |
| Instituciones: | 1Universidade Federal da Bahia, Centro das Ciencias Biologicas e da Saude, Barreiras, Bahia. Brasil 2Fundacao Oswaldo Cruz, Instituto Goncalo Moniz, Salvador, Bahia. Brasil |
| Año: | 2021 |
| Volumen: | 116 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Lipid droplets (LDs; lipid bodies) are intracellular sites of lipid storage and metabolism present in all cell types. Eukaryotic LDs are involved in eicosanoid production during several inflammatory conditions, including infection by protozoan parasites. In parasites, LDs play a role in the acquisition of cholesterol and other neutral lipids from the host. The number of LDs increases during parasite differentiation, and the biogenesis of these organelles use specific signaling pathways involving protein kinases. In addition, LDs are important in cellular protection against lipotoxicity. Recently, these organelles have been implicated in eicosanoid and specialised lipid metabolism. In this article, we revise the main functions of protozoan parasite LDs and discuss future directions in the comprehension of these organelles in the context of pathogen virulence |
| Disciplinas: | Biología |
| Palabras clave: | Protozoarios, Biología celular, Parásitos, Cuerpos lipídicos, Metabolismo lipídico, Estrés oxidativo, Eicosanoides |
| Keyword: | Protozoa, Cell biology, Parasites, Lipid bodies, Oxidative stress, Lipid metabolism, Eicosanoids |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
