| Revue: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452395 |
| ISSN: | 0074-0276 |
| Autores: | Elpidio, Laise Nayana Sala1 de Moraes, Amarilis Giaretta1 Langer, Ieda Bernadete Volkweis2 do Amaral, Greicy Cezar3 Moretti, Maria Luiza4 Garcia, Márcia Teixeira5 Angerami, Rodrigo6 Proenca Modena, José Luiz7 Bispo dos Santos, Karina7 Martini, Matheus Cavalheiro7 Parise, Pierina Lorencini7 Ayo, Christiane Maria8 de Mattos, Luiz Carlos8 Brandão, Cinara Cássia8 Nogueira, Maurício Lacerda9 Oliani, Denise Cristina Mós Vaz10 Spegiorin, Lígia Cosentino Junqueira Franco10 de Lima Neto, Quirino Alves1 Visentainer, Jeane Eliete Laguila1 |
| Instituciones: | 1Universidade Estadual de Maringa, Programa de Pos-Graduacao em Biociencias e Fisiopatologia, Maringa, Parana. Brasil 2Unidade Central de Nova Prata do Iguacu, Laboratorio, Nova Prata do Iguacu, Parana. Brasil 315 Regional de Saude do Parana, Maringa, Parana. Brasil 4Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, Sao Paulo. Brasil 5Universidade Estadual de Campinas, Divisao de Epidemiologia Hospitalar, Campinas, Sao Paulo. Brasil 6Departamento de Vigilancia em Saude Publica de Campinas, Campinas, Sao Paulo. Brasil 7Universidade Estadual de Campinas, Instituto de Biologia, Campinas, Sao Paulo. Brasil 8Faculdade de Medicina de Sao Jose do Rio Preto, Departamento de Biologia Molecular, Sao Jose do Rio Preto, Sao Paulo. Brasil 9Faculdade de Medicina de Sao Jose do Rio Preto, Departamento de Doencas Infecciosas e Parasitarias, Sao Jose do Rio Preto, Sao Paulo. Brasil 10Faculdade de Medicina de Sao Jose do Rio Preto, Departamento de Ginecologia e Obstetricia, Sao Jose do Rio Preto, Sao Paulo. Brasil |
| Año: | 2022 |
| Volumen: | 117 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | BACKGROUND Zika virus (ZIKV) is an emerging arbovirus associated with foetal malformations and neurological complications. The infection is usually associated with mild symptoms. The comparison between the allelic frequency of polymorphic genes in symptomatic infected individuals in the population can clarify the pathogenic mechanisms of ZIKV. During ZIKV infection, cytokines are produced and natural killer (NK) cells are recruited, whose activation depends on signaling pathways activated by specific receptors, such as killer cell immunoglobulin-like receptors (KIR). These molecules interact with human leukocyte antigen (HLA) class I ligands and are encoded by polymorphic genes. OBJECTIVES This study aimed to evaluate the frequency of allelic variants of the genes encoding the KIR receptors and their HLA class I ligands in 139 symptomatic ZIKV-patients and 170 controls negative for the virus, and to evaluate the role of these variants for ZIKV susceptibility. METHODS KIR and HLA class I genes were genotyped using the polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) technique. FINDINGS No significant differences in the frequency distribution of KIRs and KIR-HLA in patients compared to controls were observed. MAIN CONCLUSIONS KIR and its HLA ligands might play a minor role in ZIKV infection in the south and southeast Brazilian individuals |
| Disciplinas: | Medicina |
| Palabras clave: | Virus, Genética, Virus del Zika, Mecanismos de infección, Células asesinas naturales, Estudios de asociación |
| Keyword: | Virus, Genetics, Association studies, Zika virus, Infection mechanisms, Natural killer cells |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
