| Revue: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459470 |
| ISSN: | 0074-0276 |
| Autores: | Perce da Silva, Daiana de Souza1 Joaquim, Thays Euzebio1 Aleixo, Ana Luisa Quintella do Couto2 Motta, Juliana Pessanha Rodrigues3 Lima-Junior, Josué da Costa1 Ribeiro Alves, Marcelo2 Oliveira Ferreira, Joseli de1 Porto, Luís Cristóvão de Moraes Sobrino3 Banic, Dalma Maria1 Amendoeira, Maria Regina Reis1 |
| Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Fundacao Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro. Brasil 3Universidade do Estado do Rio de Janeiro, Laboratorio de Histocompatibilidade e Criopreservacao, Rio de Janeiro. Brasil |
| Año: | 2023 |
| Volumen: | 118 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Recurrence is a hallmark of ocular toxoplasmosis (OT), and conditions that influence its occurrence remain a challenge. Natural killer cells (NK) are effectors cells whose primary is cytotoxic function against many parasites, including Toxoplasma gondii. Among the NK cell receptors, immunoglobulin-like receptors (KIR) deserve attention due to their high polymorphism. OBJECTIVES This study aimed to analyse the influence of KIR gene polymorphism in the course of OT infection and its association with recurrences after an active episode. METHODS Ninety-six patients from the Ophthalmologic Clinic of the National Institute of Infectology Evandro Chagas were followed for up to five years. After DNA extraction, genotyping of the patients was performed by polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) utilising Luminex equipment for reading. During follow-up, 60.4% had a recurrence. FINDINGS We identified 25 KIR genotypes and found a higher frequency of genotype 1 (31.7%) with worldwide distribution. We note that the KIR2DL2 inhibitor gene and the gene activator KIR2DS2 were more frequent in patients without recurrence. Additionally, we observed that individuals who carry these genes progressed recurrence episodes slowly compared to individuals who do not carry these genes. MAIN CONCLUSIONS The KIR2DL2 and KIR2DS2 are associated as possible protection markers against ocular toxoplasmosis recurrence (OTR) |
| Disciplinas: | Medicina |
| Palabras clave: | Microbiología, Inmunología, Toxoplasmosis ocular, Receptores químicos, Recurrencia, Toxoplasma gondii |
| Keyword: | Microbiology, Immunology, Ocular toxoplasmosis, Chemical receptors, Recurrence, Toxoplasma gondii |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
