| Revue: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000400706 |
| ISSN: | 0074-0276 |
| Autores: | Leon, Luciane Almeida Amado1 Marchevsky, Renato Sergio2 Gaspar, Ana Maria Coimbra1 Garcia, Rita de Cassia Nasser Cubel3 Almeida, Adilson Jose de4 Pelajo-Machado, Marcelo5 Castro, Tatiana Xavier de3 Nascimento, Jussara Pereira do3 Brown, Kevin E5 Pinto, Marcelo Alves1 |
| Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Fundacao Oswaldo Cruz, Bio-Manguinhos, Rio de Janeiro. Brasil 3Universidade Federal Fluminense, Instituto Biomedico, Niteroi, Rio de Janeiro. Brasil 4Universidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia, Rio de Janeiro. Brasil 5Health Protection Agency, Virus Reference Department, Londres. Reino Unido |
| Año: | 2016 |
| Periodo: | Abr |
| Volumen: | 111 |
| Número: | 4 |
| Paginación: | 258-266 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | This study was conducted to analyse the course and the outcome of the liver disease in the co-infected animals in order to evaluate a possible synergic effect of human parvovirus B19 (B19V) and hepatitis A virus (HAV) co-infection. Nine adult cynomolgus monkeys were inoculated with serum obtained from a fatal case of B19V infection and/or a faecal suspension of acute HAV. The presence of specific antibodies to HAV and B19V, liver enzyme levels, viraemia, haematological changes, and necroinflammatory liver lesions were used for monitoring the infections. Seroconversion was confirmed in all infected groups. A similar pattern of B19V infection to human disease was observed, which was characterised by high and persistent viraemia in association with reticulocytopenia and mild to moderate anaemia during the period of investigation (59 days). Additionally, the intranuclear inclusion bodies were observed in pro-erythroblast cell from an infected cynomolgus and B19V Ag in hepatocytes. The erythroid hypoplasia and decrease in lymphocyte counts were more evident in the co-infected group. The present results demonstrated, for the first time, the susceptibility of cynomolgus to B19V infection, but it did not show a worsening of liver histopathology in the co-infected group |
| Disciplinas: | Medicina |
| Palabras clave: | Medicina experimental, Microbiología, Infección experimental, Parvovirus humano B19, Virus de la hepatitis A, Coinfecciones, Falla hepática aguda, Macaca fascicularis |
| Keyword: | Medicine, Experimental medicine, Microbiology, Experimental infection, Human parvovirus B19, Hepatitis A virus, Coinfections, Acute liver failure, Macaca fascicularis |
| Texte intégral: | Texto completo (Ver HTML) |
