| Revue: | Ludus vitalis |
| Base de datos: | CLASE |
| Número de sistema: | 000405325 |
| ISSN: | 1133-5165 |
| Autores: | Branch, Serena1 Stimpson, Cheryl D1 Duka, Tetyana1 Larsen, Michael D1 Janssen, William G.M2 Collins, Zachary1 Bauernfeind, Amy L1 Schapiro, Steven J3 Baze, Wallace B3 McArthur, Mark J3 Hopkins, William D4 Wildman, Derek E5 Lipovich, Leonard5 Kuzawa, Christopher W6 Jacobs, Bob7 Hof, Patrick R2 Sherwood, Chet C1 |
| Instituciones: | 1George Washington University, Washington, Distrito de Columbia. Estados Unidos de América 2Icahn School of Medicine at Mount Sinai, Departamento de Neurociencias, Mount Sinai, New York. Estados Unidos de América 3University of Texas, Departamento de Ciencias Veterinarias, Austin, Texas. Estados Unidos de América 4Georgia State University, Instituto de Neurociencias, Atlanta, Georgia. Estados Unidos de América 5Wayne State University, Detroit, Michigan. Estados Unidos de América 6Northwestern University, Departamento de Antropología, Evanston, Illinois. Estados Unidos de América 7Colorado College, Departamento de Psicologia, Colorado Springs, Colorado. Estados Unidos de América |
| Año: | 2013 |
| Volumen: | 21 |
| Número: | 40 |
| Paginación: | 177-197 |
| País: | México |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Neocortical development In humans is characterized by an extended period of synaptic proliferation that peaks in mid-childhood, with subsequent pruning through early adulthood, as well as relatively delayed maturation of neuronal arborization In the prefrontal cortex compared with sensorimotor areas. In macaque monkeys, cortical synaptogenesis peaks during early infancy and developmental changes in synapse density and dendritic spines occur synchronously across cortical regions. Thus, relatively prolonged synapse and neuronal maturation in humans might contribute to enhancement of social learning during development and transmission of cultural practices, including language. However, because macaques, which share a last common ancestor with humans ~25 million years ago, have served as the predominant comparative primate model in neurodevelopmental research, the paucity of data from more closely related great apes leaves unresolved when these evolutionary changes in the timing of cortical development became established in the human lineage. To address this question, we used immunohistochemistry, electron microscopy, and Golgi staining to characterize synaptic density and dendritic morphology of pyramidal neurons in primary somatosensory (area 3b), primary motor (area 4), prestriate visual (area 18), and prefrontal (area 10) cortices of developing chimpanzees (/Pan troglodytes/). We found that synaptogene- sis occurs synchronously across cortical areas, with a peak of synapse density during the juvenile period (3-5 y). Moreover, similar to findings in humans, dendrites of prefrontal pyramidal neurons developed later than sensorimotor areas. These results suggest that evolutionary changes to neocortical development promoting greater neuronal plasticity early in postnatal life preceded the divergence of the human and chimpanzee lineages |
| Disciplinas: | Biología, Psicología |
| Palabras clave: | Etología, Zoología, Psicología clínica, Evolución, Ontogénesis, Chimpancés, Neuronas, Sinapsis, Biología celular, Humanos |
| Texte intégral: | Texto completo (Ver PDF) |
