| Revue: | Jornal brasileiro de patologia e medicina laboratorial |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000297249 |
| ISSN: | 1676-2444 |
| Autores: | Souza, Kelen Christine do Nascimento1 Faria, Paulo Rogerio de2 Cardoso, Sergio Vitorino Dib, Luciano Lauria3 Candelori, Ignez Loyola, Adriano Mota4 |
| Instituciones: | 1Universidade Federal de Uberlandia, Faculdade de Odontologia, Uberlandia, Minas Gerais. Brasil 2Faculdade de Medicina do Triangulo Mineiro, Uberaba, Minas Gerais. Brasil 3Universidade Estadual Paulista "Julio de Mesquita Filho", Servico de Estomatologia, Sao Paulo. Brasil 4Universidade Federal de Uberlandia, Laboratório de Patologia Bucomaxilofacial, Uberlandia, Minas Gerais. Brasil |
| Año: | 2005 |
| Periodo: | Jun |
| Volumen: | 41 |
| Número: | 3 |
| Paginación: | 189-195 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | BACKGROUND: Mutations in the tumor suppressor gene TP53 have been found in many tumors, including salivary gland neoplasms (SGN). However, there is not consensus about the influence of p53 protein expression on the biological behavior of SGN. OBJECTIVES: To compare the expression of p53 between benign and malignant neoplasms, among histologic subtypes of those tumors, and among (1) tumors that did not metastasize; (2) primary lesions that emitted metastasis; and (3) metastasis of SGN, by immunohistochemistry. MATERIAL AND METHOD: It was evaluated 16 cases of pleomorphic adenoma (PA), 17 samples of primary malignant tumors that did not metastasize throughout preservation (seven adenoid cystic carcinoma [ACC] and ten mucoepidermoid carcinomas [MC]), 13 malignant neoplasms that emitted metastasis (nine ACC and four MC) and 12 regional or distant metastasis (five ACC and seven MC) by immunohistochemical detection of p53 antigen (streptavidin-biotin-peroxidase method). Statistical analyses were performed by Mann-Whitney and Kruskal-Wallis tests. p value below 0.05 was considered significant. RESULTS: A significant difference between benign and malignant lesions (p = 0.03) and among different histological types (p = 0.02) was observed, notably between PA and MC. Malignant lesions with distinct biological behavior did not differ according to this analysis |
| Resumen en portugués | Nenhuma diferença de expressão foi observada entre as neoplasias malignas quanto ao seu comportamento metastático. CONCLUSÃO: Embora a expressão de p53 tenha sido detectada em todos os subtipos de NGS, a marcação imuno-histoquímica deste antígeno não permitiu discriminar os tumores malignos quanto ao seu comportamento biológico |
| Disciplinas: | Medicina |
| Palabras clave: | Odontología, Oncología, Inmunología, Proteína p53, Tumores, Glándulas salivales, Metástasis, Pronóstico |
| Keyword: | Medicine, Dentistry, Oncology, Protein p53, Tumors, Salivary glands, Metastasis, Prognosis, Immunology |
| Texte intégral: | Texto completo (Ver HTML) |
