| Revue: | Jornal brasileiro de patologia e medicina laboratorial |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000297233 |
| ISSN: | 1676-2444 |
| Autores: | Rosa, Marilene Paladino1 Kanamura, Cristina T2 Carvalho, Marcos Brasilino de3 |
| Instituciones: | 1Hospital Heliopolis, Laboratorio de Anatomia Patologica, Sao Paulo. Brasil 2Instituto Adolfo Lutz, Sao Paulo. Brasil 3Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, Sao Paulo. Brasil |
| Año: | 2005 |
| Periodo: | Feb |
| Volumen: | 41 |
| Número: | 1 |
| Paginación: | 61-70 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | BACKGROUND: The cancer of the thyroid gland is characterized by its clinical and pathological variety. The difficult preoperative diagnosis of the follicular lesions lead to more surgical procedures of diagnostic characteristic than therapeutic. The aim of this study was to identify the immunohistochemical expression of the thyroid epithelial neoplams using monoclonal antibodies for galectin-3 and cytokeratin 19, and correlate them with pathological variables. MATERIAL AND METHODS: The expression of galectin-3 and cytokeratin 19, was immunohistochemically studied in 84 cases with diagnosis of normal tissue (n = 10), adenomatoid goiter (n = 8), follicular adenoma (n = 12), Hürthle cell adenoma (n = 3), papillary carcinoma (n = 29), follicular carcinoma (n = 8), poorly differentiated carcinoma (n = 4), Hürthle cell carcinoma (n = 4), anaplastic carcinoma (n = 6), which were selected from patients treated at the Head and Neck Surgery Department of Hospital Heliópolis, from 1984 to 1995. RESULTS: The expression of galectin-3 was observed in the cases of adenomatoid goiter (12.5%), follicular adenoma (16.7%), papillary carcinoma (96.6%), follicular carcinoma (50%), Hürthle cell carcinoma (100%) and anaplastic carcinoma (50%). Our results confirmed the significant expression of galectin-3 in the group of the malignant neoplasms, mainly in the papillary carcinoma. The expression pattern of cytokeratin 19 was different among the types of lesions; whereas in the goiters and adenomas it was weak, in the papillary carcinomas it was strong and diffuse. CONCLUSIONS: Galectin-3 and cytokeratin 19, associated, help the histopathological diagnosis, mainly in the lesions of difficult interpretation; besides they highlight atypical conditions and, thus, determine a suspicious lesion |
| Resumen en portugués | O padrão de expressão da citoqueratina 19 foi diferente entre os tipos de lesão: enquanto nos bócios e adenomas mostrou-se fraco, nos carcinomas papilíferos foi forte e difuso. CONCLUSÃO: Associadas, a galectina-3 e a citoqueratina 19 auxiliam o diagnóstico histopatológico, principalmente nas lesões de interpretação duvidosa, além de evidenciarem atipias e, com isso, determinarem uma lesão suspeita |
| Disciplinas: | Medicina |
| Palabras clave: | Endocrinología, Oncología, Inmunología, Citoqueratina, Inmunohistoquímica, Neoplasias, Galectina-3, Tiroides, Patología |
| Keyword: | Medicine, Endocrinology, Oncology, Cytokeratin 19, Immunohistochemistry, Neoplasms, Galectin 3, Thyroid gland, Pathology, Immunology |
| Texte intégral: | Texto completo (Ver HTML) |
