| Revue: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000434901 |
| ISSN: | 1677-5538 |
| Autores: | Averbeck, Marcio Augusto1 Lima, Nelson Gianni de3 Motta, Gabriela Almeida1 Beltrão, Lauro2 Abboud Filho, Nury Jafar2 Rigotti, Clarice Pereira2 Santos, William Nascimento dos2 Santos, Steven Kitzberger Jaeger dos2 Silva, Luis Fernando Batista da2 Rhoden, Ernani Luis2 |
| Instituciones: | 1Universidade Federal de Ciencias da Saude de Porto Alegre, Departamento de Pos-graduacao em Ciencias da Saude, Porto Alegre, Rio Grande do Sul. Brasil 2Complexo Hospitalar Santa Casa de Porto Alegre, Servico de Urologia, Porto Alegre, Rio Grande do Sul. Brasil 3Hospital Moinhos de Vento, Servico de Urologia, Porto Alegre, Rio Grande do Sul. Brasil |
| Año: | 2018 |
| Periodo: | Nov-Dic |
| Volumen: | 44 |
| Número: | 6 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Purpose: This study aims to evaluate the link between preoperative parameters and oxidative stress (OS) markers in the bladder wall of men undergoing open prostatectomy. Materials and Methods: From July 2014 to August 2016, men aged ≥ 50 years and presenting with LUTS were prospectively enrolled. Preoperative assessment included validated questionnaires (IPSS and OAB - V8), lower urinary tract ultrasound and urodynamics. Bladder biopsies were taken during open prostatectomy for determination of OS markers. Increased OS was defined by increased concentration of malondialdehyde (MDA) and / or decreased concentration of antioxidant enzymes (superoxide dismutase and / or catalase). P<0.05 was regarded as statistically significant. Results: Thirty - eight consecutive patients were included. Mean age was 66.36 ± 6.44 years, mean prostate volume was 77.7 ± 20.63 cm3, and mean IPSS was 11.05 ± 8.72 points. MDA concentration was increased in men with severe bladder outlet obstruction (BOO grade V - VI according to the Schaefer's nomogram) in comparison with BOO grade III - IV (p = 0.022). Patients with severe LUTS also had higher MDA concentration when compared to those with mild LUTS (p = 0.031). There was a statistically significant association between increased post - void residual urine (cut off ≥ 50 mL) and not only higher levels of MDA, but also reduced activity of SOD and catalase (p < 0.05). Conclusions: This pilot study showed that severity of LUTS and BOO were associated with increased MDA concentration in the bladder wall of men undergoing open prostatectomy. Further studies are still needed to assess the role of non - invasive biomarkers of OS in predicting bladder dysfunction in men with LUTS |
| Disciplinas: | Medicina |
| Palabras clave: | Urología, Vejiga urinaria, Obstrucción vesical, Estrés oxidativo, Preoperatorio, Prostatectomía |
| Keyword: | Urology, Urinary bladder, Vesical obstruction, Oxidative stress, Preoperative period, Prostatectomy |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
