| Revista: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000296428 |
| ISSN: | 1677-5538 |
| Autores: | Claro, Joaquim A1 Ximenes, Sergio F Nardozza Junior, Archimedes Andrade, Enrico Messina, Leonardo Srougi, Miguel |
| Instituciones: | 1Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Ribeirao Preto, Sao Paulo. Brasil |
| Año: | 2003 |
| Periodo: | Jul-Ago |
| Volumen: | 29 |
| Número: | 4 |
| Paginación: | 320-327 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | INTRODUCTION: Sildenafil citrate is a type 5 phosphodiesterase inhibitor, which has demonstrated excellent results in the treatment of erectile dysfunction. The effect of sildenafil citrate in the cavernous arteries of patients with erectile dysfunction has not been established yet. The objective of this study was to assess the effect of sildenafil citrate in the cavernous arteries of patients with erectile dysfunction, following an intracavernous injection of alprostadil. MATERIALS AND METHODS: 29 male patients, with mean age of 53.8 years (32 to 75 years), were prospectively evaluated. The mean time with complaint of erectile dysfunction was 50.5 months (6 to 168 months). Each patient was his own control. Patients underwent a measurement of peak systolic velocity before and after use of sildenafil citrate associated with 5 micrograms of alprostadil, through ultrasonic velocitometry Knoll/MIDUS® system. In the interval between measurements, approximately 15 days, patients used 3 tablets of sildenafil at home with their partners. RESULTS: Using only 5 mcg of alprostadil, average peak systolic velocity was 23.9 cm/s, and when associated to 50 mg of sildenafil it was 24.8 cm/s. Despite the increase in the flow rate caused by sildenafil, the difference was not statistically significant, Zcalculated = - 0.695 NS (Wilcoxon test). Twenty one of the 29 patients (72.4%) showed global improvement in sexual performance with the use of sildenafil citrate at home. There was not a statistically significant correlation between the global respons |
| Disciplinas: | Medicina |
| Palabras clave: | Cirugía, Farmacología, Pene, Erección, Cuerpos cavernosos, Arterias, Fosfodiesterasa |
| Keyword: | Medicine, Pharmacology, Surgery, Penis, Erection, Corpus cavernosum, Arteries, Phosphodiesterase |
| Texto completo: | Texto completo (Ver HTML) |
