Revue: | International braz j urol |
Base de datos: | PERIÓDICA |
Número de sistema: | 000434745 |
ISSN: | 1677-5538 |
Autores: | Westphalen, Antonio C1 Fazel, Farhad1 Nguyen, Hao2 Cabarrus, Miguel1 Hanley Knutson, Katryana1 Shinohara, Katsuto2 Carroll, Peter R2 |
Instituciones: | 1University of California, Department of Radiology and Biomedical Imaging, San Francisco, California. Estados Unidos de América 2University of California, Department of Urology, San Francisco, California. Estados Unidos de América |
Año: | 2019 |
Periodo: | Jul-Ago |
Volumen: | 45 |
Número: | 4 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | Purpose To determine if PSAD, PSADtz, and ADC values improve the accuracy of PI-RADS v2 and identify men whose concurrent systematic biopsy detects clinically significant cancer on areas without mpMRI visible lesions. Materials and methods Single reference-center, cross-sectional, retrospective study of consecutive men with suspected or known low to intermediate-risk prostate cancer who underwent 3T mpMRI and TRUS-MRI fusion biopsy from 07/15/2014 to 02/17/2018. Cluster-corrected logistic regression analyses were utilized to predict clinically significant prostate cancer (Gleason score ≥3+4) at targeted mpMRI lesions and on systematic biopsy. Results 538 men (median age=66 years, median PSA=7.0ng/mL) with 780mpMRI lesions were included. Clinically significant disease was diagnosed in 371 men. PI-RADS v2 scores of 3, 4, and 5 were clinically significant cancer in 8.0% (16/201), 22.8% (90/395), and 59.2% (109/184). ADC values, PSAD, and PI-RADS v2 scores were independent predictors of clinically significant cancer in targeted lesions (OR 2.25-8.78; P values <0.05; AUROC 0.84, 95% CI 0.81-0.87). Increases in PSAD were also associated with upgrade on systematic biopsy (OR 2.39-2.48; P values <0.05; AUROC 0.69, 95% CI 0.64-0.73). Conclusions ADC values and PSAD improve characterization of PI-RADS v2 score 4 or 5 lesions. Upgraded on systematic biopsy is slightly more likely with PSAD ≥0.15 and multiple small PI-RADS v2 score 3 or 4 lesions |
Disciplinas: | Medicina |
Palabras clave: | Urología, Oncología, Diagnóstico, Próstata, Radiología, Imagenología por resonancia magnética |
Keyword: | Urology, Oncology, Diagnosis, Radiology, Prostate, Magnetic resonance imaging |
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