| Revue: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000434815 |
| ISSN: | 1677-5538 |
| Autores: | Racioppi, Marco1 Gianfrancesco, Luca Di1 Ragonese, Mauro1 Palermo, Giuseppe1 Sacco, Emilio1 Bassi, Pier Francesco1 |
| Instituciones: | 1Universita Cattolica del Sacro Cuore, Fondazione Policlinico Universitario, Roma, Lazio. Italia |
| Año: | 2019 |
| Periodo: | Mar-Abr |
| Volumen: | 45 |
| Número: | 2 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Objectives: To evaluate the neutrophil-to-lymphocyte ratio (NLR) as a prognostic factor for response of high risk non muscle invasive bladder cancer (HRNMIBC) treated with BCG therapy. Materials and Methods: Between March 2010 and February 2014 in a tertiary center 100 consecutive patients with newly diagnosed HRNMIBC were retrospectively analyzed. Patients were divided according to NLR value: 46 patients with NLR value less than 3 (NLR < 3 group), and 54 patients with NLR value more than 3 (NLR ≥ 3 group). At the end of follow-up 52 patients were high grade disease free (BCG-responder group) and 48 patients underwent radical cystectomy for high grade recurrence or progression to muscle invasive disease (BCG non-responder group). The average follow-up was 60 months. Intervention: analysis and correlation of preoperative NLR value with response to BCG in terms of recurrence and progression. Results: The optimal cut-off for NLR was ≥ 3 according to the receiver operating characteristics analysis (AUC 0.760, 95% CI, 0.669-0.850). Mean NLR value was 3.65 ± 1.16 in BCG non-responder group and 2.61 ± 0.77 in BCG responder group (p = 0.01). NLR correlated with recurrence (r = 0.55, p = 0.01) and progression risk scores (r = 0.49, p = 0.01). In multivariate analysis, NLR (p = 0.02) and EORTC recurrence risk groups (p = 0.01) were associated to the primary endpoint. The log-rank test showed statistically significant difference between NLR < 3 and NLR ≥ 3 curves (p < 0.05). Conclusions: NLR value preoperatively evaluated could be a useful tool to predict BCG response of HRNMIBC. These results could lead to the development of prospective studies to assess the real prognostic value of NLR in HRNMIBC |
| Disciplinas: | Medicina |
| Palabras clave: | Urología, Oncología, Diagnóstico, Neoplasias, Vejiga urinaria, Factores pronósticos, Metástasis, Relación neutrófilos-linfocitos |
| Keyword: | Urology, Oncology, Diagnosis, Neoplasms, Urinary bladder, Prognostic factors, Metastasis, Neutrophil-lymphocyte ratio |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
