| Revue: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000296915 |
| ISSN: | 1677-5538 |
| Autores: | Antunes, Alberto A1 Nesrallah, Luciano J2 Dall'Oglio, Marcos F3 Ferreira, Yuri A Passerotti, Carlo C Leite, Katia R Ortiz, Valdemar Srougi, Miguel |
| Instituciones: | 1Universidade de Sao Paulo, Departamento de Urologia, Sao Paulo. Brasil 2Hospital Portugues de Beneficencia, Departamento de Urologia, Sao Paulo. Brasil 3Hospital Sirio Libanes, Laboratorio de Cirurgia e Patologia Molecular, Sao Paulo. Brasil |
| Año: | 2006 |
| Periodo: | Ene-Feb |
| Volumen: | 32 |
| Número: | 1 |
| Paginación: | 35-42 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | OBJECTIVE: To analyze the results of the treatment of transitional cell carcinoma (TCC) of the bladder with radical cystectomy and determine which prognostic factors can be utilized as disease-free survival and cancer-specific survival independent variables. MATERIALS AND METHODS: Medical records of 113 patients submitted to radical cystectomy and bilateral iliac lymphadenectomy between 1993 and 2005 were reviewed. The risk factors analyzed were age, sex, pathological stage, tumor grade, presence of carcinoma in situ and the presence of lymph nodes involvement. RESULTS: After a mean follow-up of 31.7 ± 28.5 months, 46 patients (40.7%) presented recurrence and 24 patients (21.2%) died due to cancer. Only pathological stage and the lymph nodes involvement became independent variables for recurrence and survival. Patients with T4 stage presented 9.6 times the risk of recurrence of the disease when compared with stage T0 patients (p = 0.010) and the patients with lymph node involvement presented 2.5 times the risk of recurrence (p = 0.047) and 3.1 times the risk of death (p = 0.022) when compared to patients without lymph nodes involvement. CONCLUSIONS: Pathological stage and the involvement of lymph nodes represented more important prognostic variables, and in the presence of advanced stage tumors (T3/T4) and involvement of lymph nodes, the institution of adjuvant treatment should be considered |
| Disciplinas: | Medicina |
| Palabras clave: | Cirugía, Oncología, Células transicionales, Vejiga, Neoplasias, Cistectomía, Pronóstico |
| Keyword: | Medicine, Oncology, Surgery, Transitional cells, Bladder, Neoplasms, Cystectomy, Prognosis |
| Texte intégral: | Texto completo (Ver HTML) |
