Revue: | Genetics and molecular biology |
Base de datos: | PERIÓDICA |
Número de sistema: | 000401310 |
ISSN: | 1415-4757 |
Autores: | Vieira-Machado, Camilla Dutra1 Tostes, Maluah1 Alves, Gabrielle1 Nazer, Julio2 Martínez, Liliana3 Wettig, Elisabeth4 Pizarro Rivadeneira, Oscar5 Diaz Caamaño, Marcela6 Larenas Ascui, Jessica7 Pavez, Pedro8 Dutra, Maria da Graca9 Castilla, Eduardo Enrique9 Orioli, Ieda Maria1 |
Instituciones: | 1Universidade Federal do Rio de Janeiro, Instituto de Biologia, Rio de Janeiro. Brasil 2Universidad de Chile, Hospital Clínico, Santiago de Chile. Brasil 3Hospital Regional de Valdivia, Valdivia. Chile 4Hospital Puerto Montt, Servicio de Neonatología, Puerto Montt. Chile 5Hospital del Salvador, Santiago de Chile. Chile 6Hospital Clínico San Borja Arriarán, Santiago de Chile. Chile 7Hospital de Cauquenes, Cauquenes, Linares. Chile 8Hospital Curicó, Curicó. Chile 9Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil |
Año: | 2016 |
Periodo: | Dic |
Volumen: | 39 |
Número: | 4 |
Paginación: | 573-579 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico |
Resumen en inglés | The presence of Native Americans, Europeans, and Africans has led to the development of a multi-ethnic, admixed population in Chile. This study aimed to contribute to the characterization of the uniparental genetic structure of three Chilean regions. Newborns from seven hospitals in Independencia, Providencia, Santiago, Curicó, Cauquenes, Valdívia, and Puerto Montt communes, belonging to the Chilean regions of Santiago, Maule, and Los Lagos, were studied. The presence of Native American mitochondrial DNA (mtDNA) haplogroups and two markers present in the non-recombinant region of the Y chromosome, DYS199 and DYS287, indicative of Native American and African ancestry, respectively, was determined. A high Native American matrilineal contribution and a low Native American and African patrilineal contributions were found in all three studied regions. As previously found in Chilean admixed populations, the Native American matrilineal contribution was lower in Santiago than in the other studied regions. However, there was an unexpectedly higher contribution of Native American ancestry in one of the studied communes in Santiago, probably due to the high rate of immigration from other regions of the country. The population genetic sub-structure we detected in Santiago using few uniparental markers requires further confirmation, owing to possible stratification for autosomal and X-chromosome markers |
Disciplinas: | Medicina |
Palabras clave: | Genética, Genética de poblaciones, Marcadores genéticos, Marcadores uniparentales, ADN mitocondrial, Cromosoma Y, Ascendencia |
Keyword: | Medicine, Genetics, Population genetics, Genetic markers, Uniparental markers, Mitochondrial DNA, Chromosome Y, Ancestry |
Texte intégral: | Texto completo (Ver HTML) |