| Revue: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459285 |
| ISSN: | 1415-4757 |
| Autores: | Araújo, Natália Meneses1 Rubio, Ileana Gabriela Sanchez1 Toneto, Nicholas Pietro Agulha1 Morale, Mirian Galliote1 Tamura, Rodrigo Esaki1 |
| Instituciones: | 1Universidade Federal de Sao Paulo, Laboratorio de Biologia Molecular do Cancer, Sao Paulo. Brasil |
| Año: | 2022 |
| Volumen: | 45 |
| Número: | 3 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Descriptivo |
| Resumen en inglés | Adenovirus was first identified in the 1950s and since then this pathogenic group of viruses has been explored and transformed into a genetic transfer vehicle. Modification or deletion of few genes are necessary to transform it into a conditionally or non-replicative vector, creating a versatile tool capable of transducing different tissues and inducing high levels of transgene expression. In the early years of vector development, the application in monogenic diseases faced several hurdles, including short-term gene expression and even a fatality. On the other hand, an adenoviral delivery strategy for treatment of cancer was the first approved gene therapy product. There is an increasing interest in expressing transgenes with therapeutic potential targeting the cancer hallmarks, inhibiting metastasis, inducing cancer cell death or modulating the immune system to attack the tumor cells. Replicative adenovirus as vaccines may be even older and date to a few years of its discovery, application of non-replicative adenovirus for vaccination against different microorganisms has been investigated, but only recently, it demonstrated its full potential being one of the leading vaccination tools for COVID-19. This is not a new vector nor a new technology, but the result of decades of careful and intense work in this field |
| Disciplinas: | Biología, Medicina |
| Palabras clave: | Virus, Terapéutica y rehabilitación, Adenovirus, Terapia génica, Vacunas, Enfermedades monogénicas, Cáncer, Revisión bibliográfica |
| Keyword: | Virus, Therapeutics and rehabilitation, Adenovirus, Gene therapy, Vaccines, Bibliographic review, Monogenic diseases, Cancer |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
