Revue: | Genetics and molecular biology |
Base de datos: | PERIÓDICA |
Número de sistema: | 000418415 |
ISSN: | 1415-4757 |
Autores: | Gamboa, Ricardo1 Huesca Gomez, Claudia1 Lopez-Perez, Vanessa1 Posadas Sánchez, Rosalinda2 Cardoso Saldaña, Guillermo2 Medina Urrutia, Aída2 Juárez Rojas, Juan Gabriel2 Soto, María Elena4 Posadas Romero, Carlos2 Vargas Alarcón, Gilberto3 |
Instituciones: | 1Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Fisiología, Ciudad de México. México 2Instituto Nacional de Cardiología Ignacio Chávez, Departmento de Endocrinología, Ciudad de México. México 3Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Biología Molecular, Ciudad de México. México 4Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Inmunología, Ciudad de México. México |
Año: | 2018 |
Periodo: | Jun |
Volumen: | 41 |
Número: | 2 |
Paginación: | 371-378 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico |
Resumen en inglés | We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1.43, Pc = 0.003). On the other hand, patients with pCAD and UCP2 A55V (rs660339) TT showed high levels of visceral abdominal fat (VAF) (Pc = 0.002), low levels of subcutaneous abdominal fat (SAF) (Pc = 0.001) and high VAT/SAT ratio (Pc < 0.001). Also, patients with UCP2 -866 (rs659366) AA showed increased levels of VAF (Pc = 0.003), low levels of SAF (Pc = 0.001) and a high VAT/SAT ratio (Pc = 0.002), whereas patients with the UCP3 -55 (rs1800849) TT presented high levels of VAF (Pc = 0.002). The results suggest the association of the UCP2 -866 (rs659366) polymorphism with risk of developing pCAD. Some polymorphisms were associated with abdominal fat levels and cardiovascular risk factors |
Disciplinas: | Medicina |
Palabras clave: | Sistema cardiovascular, Genética, Metabolismo y nutrición, Polimorfismo, Gen UCPs, Arteria coronaria prematura, Riesgo cardiovascular, Población mexicana |
Keyword: | Cardiovascular system, Genetics, Metabolism and nutrition, Polymorphism, UCPs gene, Premature coronary artery, Cardiovascular risk, Mexican population |
Texte intégral: | Texto completo (Ver PDF) |