The expression of LRRN4 was correlated with the progression and prognosis of colon adenocarcinoma (COAD) patients
Título del documento: The expression of LRRN4 was correlated with the progression and prognosis of colon adenocarcinoma (COAD) patients
Revue: Genetics and molecular biology
Base de datos: PERIÓDICA
Número de sistema: 000459211
ISSN: 1415-4757
Autores: 1
1
2
1
1
Instituciones: 1Beijing Friendship Hospital, Capital Medical University, Beijing. China
2Xuanwu Hospital, Capital Medical University, Beijing. China
Año:
Volumen: 45
Número: 1
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Our present study aims to investigate the value of LRRN4 in the progression and prognosis of COAD patients. All COAD and adjacent sample data was downloaded from TCGA database. Survival analysis was performed according to Kaplan-Meier method. The real-time quantitative PCR and immunohistochemistry analysis were conducted for validation in cell lines and tissues. The GSEA was conducted to find functional KEGG pathways. Multivariate Cox regression proportional hazard mode was used to determine whether LRRN4 expression was an independent prognostic factor. The LRRN4 expression in COAD samples were significantly higher than that in adjacent samples, which was consistent with our experiments in cell lines and tissues. Along with the increase of TNM Stage, LRRN4 expression had an increasing tendency. The COAD patients with high LRRN4 expression showed undesirable prognoses. Additionally, the TGF-β signaling pathway, WNT signaling pathway and other 25 pathways were significantly activated in the high LRRN4 expression group. In conclusion, high LRRN4 expression was closely related to the onset of COAD and it was a poor prognostic factor for COAD patients
Disciplinas: Biología,
Medicina
Palabras clave: Genética,
Gastroenterología,
Oncología,
Diagnóstico,
LRRN4,
Adenocarcinoma de colon (COAD),
Biomarcadores
Keyword: Genetics,
Gastroenterology,
Oncology,
Diagnosis,
Colon adenocarcinoma (COAD),
LRRN4,
Biomarkers
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