| Revue: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459159 |
| ISSN: | 1415-4757 |
| Autores: | Huang, Xiaoling1 Wang, Wei2 Li, Yong3 |
| Instituciones: | 1Wuhan Fourth Hospital, Department of Pulmonary and Critical Care Medicine, Wuhan, Hubei. China 2Wuhan Fourth Hospital, Department of Orthopaedics, Wuhan, Hubei. China 3Wuhan Fourth Hospital, Department of Pharmacy, Wuhan, Hubei. China |
| Año: | 2023 |
| Volumen: | 46 |
| Número: | 1 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | Chemotherapy is the main treatment option for advanced osteosarcoma, which is the most common type of primary bone malignancy. However, patients develop resistance rapidly and many succumb to the disease. Niclosamide, an anthelmintic drug, has been recently identified to display potent and selective anti-cancer activity. In this work, we show that niclosamide at sub-micromolar concentrations inhibits proliferation and migration, and induces apoptosis in both parental and chemo-resistant osteosarcoma cells, with much less toxicity in normal osteoblastic cells. Interestingly, chemo-resistant osteosarcoma cells are more sensitive to niclosamide compared to parental cells. We further identify that inhibition of β-catenin is the underlying mechanism of niclosamide’s action in osteosarcoma cells. In addition, we reveal that chemo-resistant osteosarcoma cells display increased β-catenin activity compared to parental cells, which might explain the hypersensitivity of chemo-resistant cells to niclosamide. Our work provides pre-clinical evidence that niclosamide can be repurposed for treating osteosarcoma. Our findings also suggest the therapeutic value of β-catenin to overcome osteosarcoma chemo-resistance |
| Disciplinas: | Medicina |
| Palabras clave: | Traumatología y ortopedia, Osteosarcoma, Quimiorresistencia, Niclosamida |
| Keyword: | Traumatology and orthopedics, Osteosarcoma, Niclosamide, Chemoresistance |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
