| Revue: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000331316 |
| ISSN: | 1415-4757 |
| Autores: | Marques-Salles, Terezina de Jesus1 Soares-Ventura, Eliane Maria1 Oliveira, Nathalia Lopes de1 Silva, Mariluze1 Assis, Reijane3 Morais, Vera Lucia Lins de1 Otero, Luize2 Fernandez, Teresa2 Pombo-de-Oliveira, Maria do Socorro2 Muniz, Maria Tereza Cartaxo1 Santos, Neide3 |
| Instituciones: | 1Hospital Universitario Oswaldo Cruz, Centro de Oncohematologia Pediatrica, Recife, Pernambuco. Brasil 2Instituto Nacional do Cancer, Rio de Janeiro. Brasil 3Universidade Federal de Pernambuco, Recife, Pernambuco. Brasil |
| Año: | 2008 |
| Periodo: | Mar |
| Volumen: | 31 |
| Número: | 1 |
| Paginación: | 36-38 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | We report the case of a five-month-old black male infant who had recurrent episodes of respiratory infections and also presented anemia and enlargements of the spleen, liver and lymphnodes. Hematological analysis revealed morphological abnormalities with megaloblastic dyserythropoiesis, while fetal hemoglobin assaying showed normal levels. Conventional and molecular cytogenetic analysis revealed monosomy of chromosome 7. Despite all therapeutic efforts during allogenic bone marrow transplantation, the child died due to generalized infection. The clinical and genetic distinctions between monosomy 7 syndrome and myelodysplastic disorders in childhood are discussed |
| Disciplinas: | Medicina, Biología |
| Palabras clave: | Diagnóstico, Hematología, Oncología, Pediatría, Biología celular, Genética, Leucemia, Monosomia 7, Síndrome mieloproliferativo |
| Keyword: | Medicine, Biology, Diagnosis, Hematology, Oncology, Pediatrics, Cell biology, Genetics, Leukemia, Monosomy 7, Myeloproliferative syndrome |
| Texte intégral: | Texto completo (Ver HTML) |
