Lack of association between genetic polymorphisms in IGF1 and IGFBP3 with twin births in a Brazilian population (Cândido Godói, Rio Grande do Sul)
Título del documento: Lack of association between genetic polymorphisms in IGF1 and IGFBP3 with twin births in a Brazilian population (Cândido Godói, Rio Grande do Sul)
Revue: Genetics and molecular biology
Base de datos: PERIÓDICA
Número de sistema: 000424561
ISSN: 1415-4757
Autores: 1
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1
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2
3
3
Instituciones: 1Universidade Federal do Rio Grande do Sul, Instituto de Biociencias, Porto Alegre, Rio Grande do Sul. Brasil
2Universidade Federal do Rio Grande do Sul, Instituto Nacional de Ciência e Tecnologia de Genética Médica Populacional, Porto Alegre, Rio Grande do Sul. Brasil
3Hospital de Clinicas de Porto Alegre, Servico de Genetica Medica, Porto Alegre, Rio Grande do Sul. Brasil
Año:
Periodo: Dic
Volumen: 41
Número: 4
Paginación: 775-780
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Abstract Insulin-like growth factor (IGF-1) is an important peptide hormone involved in the reproduction and fetal developmentof mammals, and it is suggested that it may influence the human twinning rate. This study aimed to test such possible association, investigating the genetic polymorphisms IGF1(CA)n and IGFBP3rs2854744 in the population fromCandido Godoi (CG), a small city located in the South of Brazil that has a high prevalence of twin births. Acase-control study was performed comprising a total of 39 cases (representing about 40% of the mothers of twinswho were born in CG after 1995) and 214 controls (mothers of non-twin children), 97 of whom were living in CG while117 were living in Porto Alegre. DNA was extracted from blood leucocytes and genotyping was performed. Accordingto the statistical analyses, there was no significant difference in the frequencies of both studied genetic poly-morphisms when comparing case group with control group. Thus, our results pointed to a lack of association be-tweenIGF1(CA)n andIGFBP3rs2854744 polymorphisms and twin births in CG, but further investigations in otherpopulations with different characteristics must be performed to confirm the role of IGF-I in human twinning
Disciplinas: Química,
Biología
Palabras clave: Bioquímica,
Reproducción y desarrollo,
Genética,
Factor de crecimiento insulínico tipo 1 (IGF-1),
Efecto fundador,
Microsatélites,
Reproducción,
Hermanamiento
Keyword: Biochemistry,
Reproduction and development,
Genetics,
Insulin-like growth factor 1 (IGF-1),
Founder effect,
Microsatellites,
Reproduction,
Twinning
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