| Revue: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000418439 |
| ISSN: | 1415-4757 |
| Autores: | Skrlec, Ivana1 Milic, Jakov1 Heffer, Marija1 Peterlin, Borut2 Wagner, Jasenka3 |
| Instituciones: | 1Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek. Croacia 2University Medical Center Ljubljana, Ljubljana. Eslovenia 3Josip Juraj Strossmayer University of Osijek, Faculty of Dental Medicine and Health, Osijek. Croacia |
| Año: | 2018 |
| Periodo: | Jun |
| Volumen: | 41 |
| Número: | 2 |
| Paginación: | 403-409 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | Disruption of endogenous circadian rhythms has been shown to increase the risk of developing myocardial infarction (MI), suggesting that circadian genes might play a role in determining disease susceptibility. We conducted a case-control study on 200 patients hospitalized due to MI and 200 healthy controls, investigating the association between MI and single nucleotide polymorphisms (SNPs) in four circadian genes (ARNTL, CLOCK, CRY2, and PER2). The variants of all four genes were chosen based on their previously reported association with cardiovascular risk factors, which have a major influence on the occurrence of myocardial infarction. Statistically significant differences, assessed through Chi-square analysis, were found in genotype distribution between cases and controls of the PER2 gene rs35333999 (p=0.024) and the CRY2 gene rs2292912 (p=0.028); the corresponding unadjusted odds ratios, also significant, were respectively OR=0.49 (95% CI 0.26-0.91) and OR=0.32 (95% CI 0.11-0.89). Our data suggest that genetic variability in the CRY2 and PER2 genes might be associated with myocardial infarction |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Diagnóstico, Genética, Enfermedades cardiovasculares, Infarto de miocardio, Polimorfismos de nucleótido único (SNPs) |
| Keyword: | Cardiovascular system, Diagnosis, Genetics, Cardiovascular diseases, Circadian rhythm, Myocardial infarction, Single nucleotide polymorphism (SNPs) |
| Texte intégral: | Texto completo (Ver PDF) |
