Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents
Título del documento: Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents
Revue: Genetics and molecular biology
Base de datos: PERIÓDICA
Número de sistema: 000424488
ISSN: 1415-4757
Autores: 1
2
1
1
2
2
2
1
Instituciones: 1Universidade Federal do Parana, Laboratorio de Polimorfismos e Ligacao, Curitiba, Parana. Brasil
2Universidade Federal do Parana, Departamento de Educacao Fisica, Curitiba, Parana. Brasil
Año:
Periodo: Dic
Volumen: 41
Número: 4
Paginación: 735-741
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés ABSTRACT Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11β1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and adolescents. DNA was genotyped by TaqMan allelic discrimination assay. The ε4 and ε2 alleles of the APOE gene were associated respectively with lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (p=0.015 and p=0.012, respectively), while the ε3 allele was associated with higher abdominal circumference (p=0.0416) and excess weight (p=0.0001). The G allele (rs846910) of the HSD11β1 gene was also associated with excess weight (p=0.039). No other association was found. Our results indicate that the ε4 and ε2 alleles could contribute to lower HDL-C and LDL-C levels, respectively, furthermore, the ε3 allele and the G allele (rs846910) of HSD11β1 gene may be risk factors for excess of weight.These findings are very important because we observed that some genetic variants influence the lipid profile and anthropometric variables early in life
Disciplinas: Biología,
Química,
Medicina
Palabras clave: Genética,
Bioquímica,
Sistema cardiovascular,
Gen PLIN4,
Gen APOB,
Gen ADIPOQ,
Gen HSD11β1
Keyword: Genetics,
Biochemistry,
Cardiovascular system,
PLIN4 gene,
APOB gene,
ADIPOQ gene,
HSD11β1 gene
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