| Revue: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459239 |
| ISSN: | 1415-4757 |
| Autores: | Wei, Bing1 Chen, Yi1 Lu, Tingyan1 Cao, Wenjiao1 Tang, Zhenhua1 Yang, Haiou1 |
| Instituciones: | 1Shanghai Jiao Tong University, School of Medicine, Shanghai. China |
| Año: | 2022 |
| Volumen: | 45 |
| Número: | 2 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | The process from high-risk human papillomavirus (HR-HPV) infection to cervical cancer is a continuous and long-term process, but the pathogenesis of the whole process is not completely clear. Here, 59 Chinese women were engaged in this study, and divided into five groups: normal healthy group, HR-HPV infections group, low-grade intraepithelial neoplasia (LSIL) group, high-SIL(HSIL) group, and cervical cancer group. With the occurrence of HR-HPV infection and the development of cervical lesions, the diversity of vaginal microbiota species was increased, and the relative abundance of Lactobacillus (L.), the dominant bacteria in maintaining vaginal microecological balance, was decreased gradually. In contrast, the abundance of Actinobacteria in the four disease groups was significantly higher than that in normal group. Furthermore L. iners may be related to the serious progression of cervical cancer. After analyzing the whole process, we found that Gardnerella(G.), Atopobium(A.) and Dialister(D.) have important effects on both persistent HR-HPV infection and the pathogenesis of cervical cancer. In addition, PICRUSt2 and KEGG results showed that the KEGG pathways enriched by the predicted genes of vaginal microbiota in cancer group included metabolic diseases, endocrine system and immune systems when compared with that in normal group. These findings may provide insights into the pathogenesis of cervical cancer, and help to improve the early detection and prevention of cervical precancerous lesions |
| Disciplinas: | Biología, Medicina |
| Palabras clave: | Bacterias, Ginecología y obstetricia, Oncología, Cáncer cervical, Microbiota vaginal, Infecciones, Neoplasias, China |
| Keyword: | Bacteria, Gynecology and obstetrics, Oncology, Cervical cancer, Vaginal microbiota, Infections, Neoplasias, China |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
