| Revue: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000420009 |
| ISSN: | 1415-4757 |
| Autores: | Xinju Zhang1 Lei Jin2 Zhiyuan Wu3 Weizhe Ma1 Yuming Chen1 Gang Chen4 Lixin Wang5 Ming Guan1 |
| Instituciones: | 1Fudan University, Huashan Hospital, Shanghai. China 2Shanghai University of Medicine and Health Sciences, College of Allied Health Professions, Shanghai. China 3Fudan University, Department of Laboratory Medicine, Shanghai. China 4Fudan University, Department of Geriatrics, Shanghai. China 5Ningxia Medical University, The Medical Laboratory, Yinchuan. China |
| Año: | 2018 |
| Periodo: | Sep |
| Volumen: | 41 |
| Número: | 3 |
| Paginación: | 578-584 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an efficient indicator of potential allopurinol hypersensitivity syndrome. In this study, rs9263726 and HLA-B*58:01 were detected in all samples. For samples of individuals whose rs9263726 genotypes were not consistent with HLA-B*58:01, we did high-resolution typing of HLA-B gene to further confirm the correlation of rs9263726 genotype and special HLA-B alleles. We confirmed that the linkage disequilibrium between rs9263726 and HLA-B*58:01 was more significant in the Han ethnic group (r 2 =0.886, D’=1.0) than in the Tibet and Hui ethnic groups (for Tibetan, r 2 =0.606, D’=0.866; for Hui, r 2 =0.622, D’=0.924). For Han Chinese, samples with the GG genotype of rs9263726 did not carry HLA-B*58:01, while AA genotype samples were homozygous carriers of HLA-B*58:01. However, GA genotype samples of rs9263726 required a more sophisticated HLA-B genotyping assay before it was possible to identify whether they were HLA-B*58:01 carriers or not. For Tibetan and Hui, the linkage disequilibrium between rs9263726 and HLA-B*58:01 was not significant. Therefore, rs9263726 cannot replace HLA-B*58:01 in these two groups |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Genética, Química farmacéutica, Terapéutica y rehabilitación, Genotipo rs9263726, Gen HLA-B*58:01, Allopurinol, Reacción de hipersensibilidad (HR), Etiqueta SNP |
| Keyword: | Genetics, Medicinal chemistry, Therapeutics and rehabilitation, rs9263726 genotype, HLA-B*58:01 gene, Allopurinol, Hypersensitive reaction (HR), Tag SNP |
| Texte intégral: | Texto completo (Ver PDF) |
