| Revista: | Electronic journal of biotechnology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000357873 |
| ISSN: | 0717-3458 |
| Autores: | Shuai, Cijun1 Nie, Yi1 Gao, Chengde1 Lu, Haibo1 Hu, Huanlong1 Wen, Xuejun2 Peng, Shuping3 |
| Instituciones: | 1Central South University, State Key Laboratory of High Performance Complex Manufacturing, Changsha. China 2Medical University of South Carolina, Department of Regenerative Medicine & Cell Biology, Charleston, Carolina del Sur. Estados Unidos de América 3Central South University, Cancer Research Institute, Changsha. China |
| Año: | 2012 |
| Volumen: | 15 |
| Número: | 6 |
| País: | Chile |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Cracks often occur when nano-hydroxyapatite bone scaffolds are fabricated with selective laser sintering, which affect the performance of scaffolds. In this study, a small amount of poly (l-lactide acid) (PLLA) was added into nano-hydroxyapatite (nano-HAP) powder by mechanical blending in order to improve the sintering properties. The nano-HAP powder combined with 1wt % PLLA was sintered under different laser power (5W, 7.5W, 10W, 12.5W, 15W and 20W). The fabricated scaffolds were characterized using Scanning Electron Microscope (SEM), X-ray Diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and Micro Hardness Tester. The results showed that nano-HAP particles grew up quickly with the laser power increasing, and there were many strip-like cracks on the surface of sintering zone. The cracks gradually reduced until disappeared when the laser power increased to 15W, together with a great improvement of density. Large pores were observed on the specimen when the laser power further increases, accompanied with the decomposition of HAP into β-tricalcium phosphate (β-TCP) and tetracalcium phosphate (TTCP). And the optimum parameters were eventually obtained with laser power of 15W, scanning speed of 1000 mm/min, powder bed temperature of 150ºC, laser spot diameter of 2 mm and layer thickness of 0.2 mm. We summarized that the molten PLLA enhanced the particle rearrangement of nano-HAP by capillary force and may absorb thermal stress in laser sintering process, while PLLA would be oxidized gradually until completely excluded from the sintered nano-HAP scaffolds, which was confirmed by FTIR analysis. This study provides a novel method to improve the sintering properties of nano-HAP with no adverse effects which would be used in the application of bone tissue engineering potentially |
| Disciplinas: | Biología |
| Palabras clave: | Biotecnología, Biomateriales, Hidroxiapatita, Microestructuras, Dureza, Propiedades térmicas |
| Keyword: | Biology, Biotechnology, Biomaterials, Hydroxyapatite, Microstructures, Hardness, Thermal properties |
| Texto completo: | Texto completo (Ver HTML) |
